Linkerology

15/06/2021

Thiol- and Amine Reactive Crosslinkers

Iris Biotech offers hetero-bifunctional crosslinkers bearing an N-hydroxysuccinimide (NHS) ester and a maleimide group suitable for the reaction with amine- and thiol-containing molecules.

News Product of the month Linkerology

15/06/2021

PotM: Pyridyldithiols as Precursors for Disulfide-Based (Self-Immolative) Linkers

Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.

PotM: Pyridyldithiols as Precursors for Disulfide-Based (Self-Immolative) Linkers

News Linkerology Building Blocks Product Focus

20/04/2021

Fmoc-MeDbz-OH – Available on Large Scale

Are you using the Fmoc-MeDbz-OH Dawson Linker in large scale on a regular basis? A robust and economic processallows us to promptly provide you with kg quantities at competitive prices and in high quality.

Fmoc-MeDbz-OH – Available on Large Scale

News Linkerology Building Blocks

20/04/2021

DACNs for Strain-Promoted Azide-Alkyne Cycloadditions (SPAAC)

Herein we present substituted diazacyclononynes (DACNs) as versatile tools for metal-free strain-promoted Click Chemistry that are characterized by high reactivity and stability, both thermally and chemically.

DACNs for Strain-Promoted Azide-Alkyne Cycloadditions (SPAAC)

News Product of the month Linkerology

23/03/2021

Ramage Linker

An efficient, versatile linker developed for the synthesis of C-terminal primary/secondary amides and hydrazides as well as peptide alcohols, which is compatible with SPPS and suppresses side reactions.

Linkerology Product Focus

26/01/2021

Trimethyl Locks

The sterical interference of three closely positioned methyl groups favors amide cleavage and payload release upon lactonization. This cascade can be induced by various triggers. Read on to find out more.

Product of the month Linkerology

26/01/2021

PotM: Disulfide-Based Self-Immolative Linkers

The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.

PotM: Disulfide-Based Self-Immolative Linkers

News Linkerology Knowledge Base

21/01/2021

Linkerology

Check out our latest video summarizing our capabilities and knowledge on linker technologies

News Linkerology Building Blocks Product Focus

25/11/2020

Thiol-reactive Linkers for ADCs

The thiosuccinimide linkage is a prominent connective motif resulting from the reaction of a thiol and an alkyl maleimide. Read on to learn more about its applications and potential improvements.

News Linkerology

27/10/2020

Valine-Citrulline Based Enzymatically Cleavable Linkers

Iris Biotech presents its selection of Val-Cit-based linkers, a dipeptide motif frequently utilized for the development of ADCs with increased serum stability and high cleavage efficiency.