Name: Biotin-PABA
SKU: LS-4200
Availability: InStock

Grouped product items

Cantidad

Unidad de venta

Precio

Unidad de almacenamiento de stock (SKU)

Disponibilidad

250 mg

400,00 €

LS-4200.0250

description

Biotin-PABA is used as substrate for biotinidase, which cleaves biotin amide to release biotin in vivo. As byproduct, para amino benzoic acid is released, which can be quantified by either fluorescent or colorimetric methods. Biotin is an essential coenzyme for certain carboxylases and is used to modify histones and regulate gene transcription. Biotinidase has key roles in intestinal absorption of biotin, the transport of biotin in plasma, and in the regulation of histone biotinylation.

references

Quantitative Analytical Method for the Determination of Biotinidase Activity in Dried Blood Spot Samples; E. Szabó, I. Szatmári, L. Szõnyi, Z. Takáts; Anal. Chem. 2015; 87(20): 10573-10578. https://doi.org/10.1021/acs.analchem.5b02996.

Triazole biotin: a tight-binding biotinidase-resistant conjugate; A. I. Germeroth, J. R. Hanna, R. Karim, F. Kundel, J. Lowther, P. G. N. Neate, E. A. Blackburn, M. A. Wear, D. J. Campopiano, A. N. Hulme; Org. Biomol. Chem. 2013; 11: 7700-7704. https://doi.org/10.1039/C3OB41837E.

Design and Synthesis of ATP-Based Nucleotide Analogues and Profiling of Nucleotide-Binding Proteins; J. C. Wolters, G. Roelfes, B. Poolman; Bioconjugate Chem. 2011; 22(7): 1345-1353. https://doi.org/10.1021/bc100592q.

Biotinyl-methyl 4-(amidomethyl) benzoate is a competitive inhibitor of human biotinidase; K. A. Kobza, K. Chai, G. Sarath, J. M. Takacs, J. Zempleni; J. Nutr. Biochem. 2008; 19(2): 826-832. https://doi.org/10.1016/j.jnutbio.2007.11.002.

Qualitative colorimetric ultramicroassay for the detection of biotinidase deficiency in newborns; E. C. González, N. Marrero, A. Frómeta, D. Herrera, E. Castells, P. L. Pérez; Clin. Chim. Acta 2006; 369(1): 35-39. https://doi.org/10.1016/j.cca.2006.01.009.

Artificial Metalloenzymes: (Strept)avidin as Host for Enantioselective Hydrogenation by Achiral Biotinylated Rhodium-Diphosphine Complexes; M. Skander, N. Humbert, J. collot, J. Gradinaru, G. Klein, A. Loosli, J. Sauser, A. Zocchi, F. Gilardoni, T. R. Ward; J. Am. Chem. Soc. 2004; 126(44): 14411-14418. https://doi.org/10.1021/ja0476718.

Purification and characterization of human serum biotinidase; J. Chauhan, K. Dakshinamurti; J. Biol. Chem. 1986; 261(9): 4268-4275. https://doi.org/10.1016/S0021-9258(17)35656-9.

* Disclaimer

We refer to our general terms and conditions.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.