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Pepstatin A
Nombre químico: [3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid] // Sinónimos: Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-L-val-L-val-statinyl-L-alastatine
- Nº Artículo:LS-3910
- Nº CAS:26305-03-3
- Fórmula:C34H63N5O9
- Storage temperature:-20°C
- Masa molecular:685,90 g/mol
from A petición
description
A potent, reversible, highly selective inhibitor of acid proteases (aspartate proteases) that has been shown to inhibit HIV and MMTV proteases. Pepstatin A shows no activity
against thiol proteases.
Potential targets: Pepsin, Renin, Cathepsin D, Chymosin, Protease B, retroviral Proteases
references
Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria; C. S. Oliveira, H. Pereira, S.
Alves, L. Castro, F. Baltazar, S. R. Chaves, A. Preto and M. Corte-Real; Cell death & disease 2015; 6: e1788. doi:10.1038/cddis.2015.157
Inhibitory effects of pepstatin A and mefloquine on the growth of Babesia parasites; T. Munkhjargal, M. AbouLaila, M. A. Terkawi, T. Sivakumar, M. Ichikawa, B. Davaasuren, T.
Nyamjargal, N. Yokoyama and I. Igarashi; Am J Trop Med Hyg 2012; 87: 681-8. doi:10.4269/ajtmh.2012.12-0218
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion; Y. Liu, Y. Zhou and K. Zhu; PLoS One 2012; 7: e45910. doi:10.1371/journal.pone.0045910
A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function; S. I. van Kasteren, I. Berlin, J. D. Colbert, D. Keane, H. Ovaa and C. Watts; ACS Chemical Biology 2011;
6: 1198-1204. doi:10.1021/cb200292c
Induction of cell death in neuroblastoma by inhibition of cathepsins B and L; R. Colella, G. Lu, L. Glazewski, B. Korant, A. Matlapudi, M. R. England, C. Craft, C. N. Frantz and
R. W. Mason; Cancer Lett 2010; 294: 195-203. doi:10.1016/j.canlet.2010.01.037
Pepstatin, a new pepsin inhibitor produced by Actinomycetes; H. Umezawa, T. Aoyagi, H. Morishima, M. Matsuzaki and M. Hamada; The Journal of antibiotics 1970; 23: 259-62.
T. Munkhjargal, M. AbouLaila, M. A. Terkawi, T. Sivakumar, M. Ichikawa, B. Davaasuren, T. Nyamjargal, N. Yokoyama, and I. Igarashi(2012) Inhibitory Effects of Pepstatin A and
Mefloquine on the Growth of Babesia Parasites. Am. J. Trop. Med. Hyg., 87(4), 681-688.
H. Umezawa, T. Aoyagi, H. Morishima, M. Matsuzaki, M. Hamada. (1970) Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo), 23(5), 25962.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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