Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Contacto rápido
Por favor envíeme más información sobre
Ramage-Linker
Nombre químico: (R,S)-2-{[5-(9-Fluorenylmethyloxycarbonylamino)-dibenzo[a,d]cycloheptane-2-yl]oxy}-acetic acid // Sinónimos: Fmoc-Suberol
- Nº Artículo:RL-1029
- Nº CAS:212783-75-0
- Fórmula:C32H27NO5
- Storage temperature:2-8°C
- Masa molecular:505,58 g/mol
from 180,00 €
description
Alternative to the commonly used Rink-amide linker. The three-circular structure of the Ramage linker prevents fragmentation of the linker during cleavage from the resin followed by back alkylation. A common phenomenon observed during peptide synthesis with the open structure of the Rink-amide linker. Hence, Ramage linker delivers peptides with higher purity and less impurities, than peptides produced with the Rink-amide linker. Ramage resin is particularly recommended for C-terminal Phe, Tyr and Ile. After attachment to a resin and Fmoc removal standard SPPS can be carried out with conventional Fmoc/tBu protocols Peptide amides can be released from the resin with 50% TFA in DCM or 95% aqueous TFA.
references
Potassium channel modulation by a toxin domain in matrix metalloprotease 23; S. Rangaraju, K. K. Khoo, Z. P. Feng, G. Crossley, D. Nugent, I. Khaytin, V. Chi, C. Pham, P. Calabresi, M. W. Pennington, R. S. Norton and K. G. Chandy; J Biol Chem 2010; 285: 9124-36. https://doi.org/10.1074/jbc.M109.071266
An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii; R. V. Baudinette, P. Boontheung, I. F. Musgrave, P. A. Wabnitz, V. M. Maselli, J. Skinner, P. F. Alewood, C. S. Brinkworth and J. H. Bowie; FEBS J 2005; 272: 433-43. https://doi.org/10.1111/j.1742-4658.2004.04483.x
Evaluation of some fluorogenic substrates for continuous assay of aminopeptidase P; S. J. Hawthorne, P. Harriott, J. Lim, A. J. Turner, B. Walker and C. H. Williams; Anal Biochem 1997; 253: 13-7. https://doi.org/10.1006/abio.1997.2320
Design of a versatile linker for solid phase peptide synthesis: Synthesis of C-terminal primary/seconary amides and hydrazides; R. Ramage, S. L. Irving and C. McInnes; Tetrahedron Letters 1993; 34: 6599-6602. https://doi.org/10.1016/0040-4039(93)88115-y
* Disclaimer
We refer to our general terms and conditions.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
¿Necesita más información sobre este producto?
ponerse en contacto
Folletos y volantes
¡Otros productos que también podrían interesarle!
