MC-Val-Ala-PAB-Cl

Nom chimique: 6-Maleimidohexanoyl-valyl-alanyl-(4-aminobenzyl chloride) // Synonymes: Mal-hexanoyl-Val-Ala-PAB-Cl, MC-VA-PAB-Cl,N-((S)-1-(((S)-1-((4-(chloromethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide,6-Ma ileimidohexanoyl-VA-(4-aminobenzyl chloride)

n° Art.:ADC1700
n° CAS:2983182-03-0
Formule:C₂₅H₃₃ClN₄O₅
Storage temperature:-20°C
Masse moléculaire:521,01 g/mol

from 500,00 €

Grouped product items
Nombre	Unité de vente	Prix	SKU	Disponibilité
	100 mg	500,00 €	ADC1700.0100	<10 jour ouvrables
	250 mg	1 000,00 €	ADC1700.0250	<10 jour ouvrables
Fiches de données de sécurité

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description

Linker for Antibody-Drug-Conjugation (ADC). In contrast to the hydroxybenzyl derivative ADC1270 the chloride is able to react with tertiary amines to form a linked quarternary amine. The Val-Ala will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome the ADC payload will be released only in the cell.

references

Laurent Ducry (ed.), Antibody-Drug Conjugates, Methods in Molecular Biology, vol. 1045, Springer Science+Business Media, LLC 2013; https://doi.org/10.1007/978-1-62703-541-5_5.

Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates; L. R. Staben, S. G. Koenig, S. M. hear, R. Vandlen, D. Zhang, J. Chuh, S.-F. Yu, C. Ng, J. Guo, Y. Liu, A. Fourie-O’Donohue, M. Go, X. Linghu, N. L Segraves, T. Wang, J. Chen. B. Wei, G. D. L. Phillips, K. Xu, K. R. Kozak, S. Mariathasan, J. A. Flygare, T. H. Pillow; Nat. Chem. 2016; 8: 1112-1119. https://doi.org/10.1038/NCHEM.26.

Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors; L. R. Staben, S.-F. Yu, J. Chen, G. Yan, Z. Xu, G. Del Rosario, J. T. Lau, L. Liu, J. Guo, B. Zheng, J. dela Cruz-Chuh, B.-C. Lee, R. Ohri, W. Cai, H. Zhou, K. R. Kozak, K. Xu, G. D. L. Phillips, J. Lu, J. Wai, A. G. Polson, T. H. Pillow; ACS Med. Chem. Lett. 2017; 8(10): 1037-1041. https://doi.org/10.1021/acsmedchemlett.7b00243.

Highly Efficient Synthesis of a Staphylococcus aureus Targeting Payload to Enable the First Antibody-Antibiotic Conjugate; X. Linghu, N. L. Segraves, I. Abramovich, N. wong, B. Müller, N. Neubauer, S. Fantasia, S. Rieth, S. Bachmann, M. Jansen, C. G. Sowell, D. Askin, S. G. Koenig, F. Gosselin; Chem. Eur. J. 2018; 24(12): 2837-2840. https://doi.org/10.1002/chem.201705392.

Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates; P. J. Burke, J. Z. Hamilton, T. A. Pires, J. R. Setter. J. H. Hunter, J. H. Cochran, A. B. Waight, K. A. Gordon, B. E. Toki, K. K. Emmerton, W. Zeng, I. J. Stone, P. D. Senter, R. P. Lyon, S. C. Jeffrey; Mol. Cancer Ther. 2016; 15(5): 938-954. https://doi.org/10.1158/1535-7163.MCT-16-0038.

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