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Drug Delivery

09/02/2017

Click Chemistry in DNA Synthesis

Click Chemistry in DNA Synthesis - Applications and Procedures in DNA Synthesis

09/02/2017

Standard approaches

Diethyl-acetamidomalonate Route: The probably most widely used first approach to unnatural amino acids goes via alkylation of diethyl acetamidomalonate.

Custom Synthesis

09/02/2017

Specific platforms

Asymmetric Phase-Transfer Reaction Phase-transfer alkylations e.g. with the chiral Maruoka catalyst result in unique α-mono substituted and α,α-disubstituted unnatural amino acids.

Custom Synthesis

09/02/2017

Homologization of natural amino acids

Several platforms are available to display the whole assortment of homo-amino acids, as well as the higher homologues β2-, β3-, their double substituted derivatives β2,2,2-, β3,3-, and corresponding γ-amino acids.

Custom Synthesis

09/02/2017

α-Methyl and β,β-dimethyl amino acids

α-Methyl and alkyl-amino acids can be produced by a number of platforms, where the (2S,4S)-4-methyl-2-phenyloxazolidin-5-one scaffold is one of the most popular one.

Custom Synthesis

09/02/2017

Trifluoromethylated and other Fluoro-amino acids

The incorporation of trifluoromethyl group carrying building blocks into peptides results in increased chemical and thermal stability, increased resistance to degradation by proteases, and enhanced lipophilicity.

Custom Synthesis

09/02/2017

Arginine Analogues

Trypsin (EC 3.4.21.4), an endopeptidase and natural protease found in the digestive system, cleaves peptide chains and proteins predominantly at the carboxyl side of the amino acids Lys and Arg (except when followed by Pro).

Custom Synthesis

09/02/2017

Specific Linkers

The variations for linkers are endless, as in our catalogue program already hundreds of different derivatives are available for conjugation of small molecules, biomolecules and surfaces to each other.

Custom Synthesis

09/02/2017

Spermines, spermidines and other Polyamines

Polyamines such as ethylene diamine and its higher homologues are important feedstocks for the chemical industry. Compounds like putrescine, spermidine, and spermine play important roles in both eukaryotic and prokaryotic cells and show many other different biological functions.

Custom Synthesis

09/02/2017

Maillard Reaction Products

Proteins contained in meat and other comestible goods are usually rich in the amino acids arginine and lysine. The side chain func- tional groups of Arg and Lys react with reducing carbohydrates such as glucose or lactose to form Amadori reaction products.