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Blog - Amino Acids - Page 4
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Process Development – From Discovery to Scale-up
Ongoing research efforts lead to the discovery of innovative building blocks and new APIs. However, for industrial applications, upscaling is required. Herein, we share the process development for Fmoc-Cys(Msbh)-OH.
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Cyanobenzothiazole (CBT) Derivatives for “Click” Conjugation
Discover the cyanobenzothiazole (CBT) click reaction, a not (yet) so well-known biocompatible and bio-orthogonal mechanism faster than the famous azide-alkyne cycloaddition (CuAAC).
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PotM: Safety Catch - Orthogonally Protected Amino Acids
Add a new dimension of orthogonality to your peptide synthesis by using Safety-Catch arylalkyl sulfoxide protecting groups! This newsletter tells you about benefits and usage – Read on!
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Photoaffinity Labeling by Diazirine Building Blocks
Discover our diazirine-substituted building blocks suitable for the analysis of protein-protein and RNA-protein interactions via proximity labeling upon photoactivation. Read on for more information!
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Carbamidomethylated Cysteine as SPPS Building Block
Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and carbamido-methylated protein fragments by standard SPPS without error-prone modification reactions.
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Fatty Di-Acids
Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!
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Non-canonical Tryptophan Derivatives
Non-canonical Tryptophan analogs can help to improve your API’s performance in terms of potency, specificity, and stability. We offer various substituted Trp derivatives also available in small quantities for screening.
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PotM: Argpyrimidine Building Block for SPPS
Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!
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Acylation Efficiencies on Ser and Thr Pseudoproline Monomers
In two joint studies together with Prof. F. Albericio we investigated the coupling efficiencies of Ser and Thr pseudoproline monomers and their use for the synthesis of inaccessible peptide sequenes. Read on!
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Abraligabra - Reagents and Building Blocks for Chemical Ligation
We can’t get enough of new products and innovations! Read this blog to get detailed information on the cyanylating reagent NTCB as well as selenocysteine amino acids, both useful tools for peptide ligation.
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