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Blog - Product of the month - Page 5
Herein we highlight products which we consider to be of special interest to our customers.
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PotM: Guanidino-Proline as rigid Arginine mimic
Interested in structure activity studies on your Arginine containing peptide or further optimization for improved receptor binding? Explore our guanidino Proline derivatives as rigid Arginine mimics.
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PotM: Asp(CSY) – Tackling Aspartimide Formation
Fmoc-Asp(CSY)-OH – an innovative building block to suppress aspartimide formation during peptide synthesis by utilizing cyanosulfurylide as carboxylic acid protecting group. Read on to find our more!
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Ramage Linker
An efficient, versatile linker developed for the synthesis of C-terminal primary/secondary amides and hydrazides as well as peptide alcohols, which is compatible with SPPS and suppresses side reactions.
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PotM: SIT – A New Cysteine Protecting Group
The new disulfide-based protecting group sec-isoamyl mercaptan (SIT) is fully compatible with Fmoc- and Boc-SPPS and can easily be removed reductively upon addition of dithiothreitol.
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PotM: Disulfide-Based Self-Immolative Linkers
The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.
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Product of the Month: Fluorinated Amino Acids
One approach for the design of bioactive peptides with improved pharmacological properties is the derivatization of amino acid building blocks with fluorine. Find out more about the advantages of fluorinated peptides.
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Product of the Month: Fluorescent SARS-CoV-2 Protease Substrates
Mpro is a key enzyme of coronaviruses (coronaviridae) and thus an attractive drug target. Iris Biotech offers fluorescent substrates, which can be used to perform various types of screenings and to identify potential inhibitors of COVID-19.
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Product of the Month: Imatinib And Other Linked Kinase Inhibitor Analogues
Iris Biotech offers various linked kinase inhibitors including analogues of Gefitinib, Imatinib, Sunitinib, Staurosporine and many more, which can easily be conjugated to other biomolecules, if desired. Have a look and read more.
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Product of the Month: Novel Fmoc-Amino Acids for Convenient Access to HDAC Inhibitors
Find out more about those building blocks with side chains able to coordinate metal ions, and why peptide-based HDACis are intriguing synthetic targets.
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Product of the Month: Dde-based Linkers
Placing Dde as one terminal group of a linker and a functional group prone for conjugation as the other or using Dde as the central connective portion of a linker, allows for the creation of new bifunctional linkers.
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