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Fmoc-L-Asn(EDA-N3)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-gamma-(2-azidoethyl)-L-asparagine // Synonymes: Fmoc-Asn(EDA-N3)-OH, Fmoc-Asn-Azide, Fmoc-Asn-N3, N-alpha-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-gamma-(2-azidoethyl)-L-asparagine
- n° Art.:FAA8605
- n° CAS:2616562-74-2
- Formule:C21H21N5O5
- Storage temperature:2-8°C
- Masse moléculaire:423,43
- Pureté:min. 98%
- Pureté Énantiomérique:min. 99,7%
from 162,00 €
description
This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 µg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II.
references
Scaling amatoxin synthesis with an improved route to (2S,3R,4R)-dihydroxyisoleucine exemplified by a toxic, clickable alpha-amanitin analog; C. M. Hambira, K. Matinkhoo, A. Pryyma, B. O. Patrick, D. M. Perrin; J. Org. Chem. 2021, 86(7): 5362-5370. https://doi.org/10.1021/acs.joc.0c03022.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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