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Fmoc-L-Ala(3-Cl)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-3-chloro-L-alanine // Synonymes: (R)-2-[(9-Fluorenylmethyloxycarbonyl)amino]-3-chloro-propionic acid, Fmoc-beta-chloro-L-alanine, Fmoc-3-chloro-L-alanine, Fmoc-Ala(3-Cl)-OH
- n° Art.:FAA3170
- n° CAS:212651-52-0
- Formule:C18H16ClNO4
- Storage temperature:2-8°C
- Masse moléculaire:345,78 g/mol
- Pureté:min. 98%
- Pureté Énantiomérique:min. 99,7%
from 98,00 €
description
The Chlorine function in this building block is labile and reactive. Depending on reaction conditions, it is prone to nucleophilic substitution or to elimination. Thus, it is not primarily a building block to permanently introduce 3-Chloroalanine into a peptide, but rather to use the function for further modification such as cyclic peptide ring closure or introduction of Dehydroalanine. However, there are also publications (see below) reporting introduction of 3-Chloroalanine into peptides without elimination.
references
Halogen Bonding: A Powerful Tool for Modulation of Peptide Conformation; E. Danelius, H. Andersson, P. Jarvoll, K. Lood, J. Gräfenstein, M. Erdélyi; Biochemistry 2017; 56: 3265-3272. https://doi.org/10.1021/acs.biochem.7b00429
Cyclization of Peptides by using Selenolanthionine Bridges; A. D. de Araujo, M. Mobli, G. F. King, P. F. Alewood; Angew. Chem. Int. Ed. 2012; 51: 10298-10302. https://doi.org/10.1002/anie.201204229
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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