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Fmoc-L-trans-Hyp(NHBoc)-OH
Nom chimique: Fmoc-4-(Boc-amino)oxy)-proline (2S,4R) // Synonymes: Fmoc-Pro(4-O-NHBoc)-OH, (2S,4R)-1-(9-fluorenmethyloxycarbonyl)-4-(((tert-butoxycarbonyl)amino)oxy)pyrrolidine-2-carboxylic acid,(2S,4R)-Fmoc-4-(((tert-butoxycarbonyl)amino)oxy)-pyrrolidine-2-carboxy lic acid, Fmoc-4-(((tert-butoxycarbonyl)amino)oxy)
- n° Art.:FAA8455
- n° CAS:1015426-45-5
- Formule:C25H28N2O7
- Storage temperature:2-8°C
- Masse moléculaire:468,50 g/mol
from 600,00 €
description
Aminooxy-containing proline analogues bearing Fmoc/Boc protection suitable for the incorporation into peptides using Fmoc protocols. Deprotection of the aminooxy-function after completion of the peptide synthesis allows for oxime formation through reaction with aldehydes. This allows the post solid-phase synthesis of diverse derivative for structure-activity studies.
references
Protected aminooxyprolines for expedited library synthesis: Application to Tsg101-directed proline-oxime containing peptides; F. Liu, A. G. Stephen, R. J. Fisher, T. R. Burke; Med. Chem. Lett. 2008; 18: 1096-1101. https://doi.org/10.1016/j.bmcl.2007.12.003.
SAR by Oxime-Containing Peptide Libraries: Application to Tsg101 Ligand Optimization; F. Liu, A. G. Stephen, A. A. Waheed, M. J. Aman, E. O. Freed, R. J. Fisher, T. R. Burke; Chembiochem 2008; 9: 2000-2004. https://doi.org/10.1002/cbic.200800281.
Eludication of New Binding Interactions with the Human Tsg101 Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands; S.-E. Kim, F. Liu, Y. J. Im, A. G. Stephen, M. J. Fivash, A. A. Waheed, E. O. Freed, R. J. Fisher, J. H. Hurley, T. R. Burke; ACS Med. Chem. Lett. 2011; 2: 337-341. https://doi.org/10.1021/ml1002579.
Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification; F. Li, J.-E. Park, W.-J. Qian, D. Lim, A. Scharow, T. Berg, M. B. Yaffe, K. S. Lee, T. R. Burke; ACS Chem. Biol. 2012; 7: 805-810. https://doi.org/10.1021/cb200469a.
Cross-Linked Collagen Triple Helices by Oxime Ligation; N. B. Hentzen, L. E. J. Smeenk, J. Witek, S. Riniker, and H. Wennemers; J. Am. Chem. Soc. 2017; 139: 12815-12820. https://doi.org/10.1021/jacs.7b07498.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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