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Fmoc-L-Dab(Boc-Thz)-OH
Nom chimique: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-((R)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxamido)butanoic acid // Synonymes: Fmoc-Dab(Boc-Thz)-OH
- n° Art.:FAA9330
- n° CAS:2968514-54-5
- Formule:C28H33N3O7S
- Storage temperature:2-8°C
- Masse moléculaire:555,65 g/mol
from 450,00 €
description
Bicyclic peptides have high potential as next generation pharmaceuticals, e.g., to disrupt the difficult to target interactions between proteins. For controlled cyclization, selective reactivities are required. Our 1,2-aminothiol and 1,3-thiazole building blocks yield the ideal combination for this purpose, and, in addition, are compatible with SPPS. Besides, when used N-terminally, 1,2-aminothiols are useful for connecting peptide fragments by native chemical ligation (NCL).
references
Biocompatible and Selective Generation of Bicyclic Peptides; S. Ullrich, J. George, A. E. Coram, R. Morewood, C. Nitsche; Angew. Chem. Int. Ed. 2022; 61(43): e202208400. https://doi.org/10.1002/anie.202208400
Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents; A. Istrate, M. Geeson, C. Navo, B. Sousa, M. Marques, R. Taylor, T. Journeaux, S. Oehler, M. Mortensen, M. Deery, A. Bond, F. Corzana, G. Jiménez-Osés, G. Bernardes; JAmChemSoc. 2022; 144: 10396-10406. https://doi.org/10.1021/jacs.2c02185
Recent advances in N- and C-terminus cysteine protein bioconjugation; R. Spears, V. Chudasama; CurrOpinChemBiol. 2023; 75: 102306. https://doi.org/10.1016/j.cbpa.2023.102306
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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