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H-L-Tyr(2-azidoethyl)-OH
Nom chimique: O-2-azidoethyl-tyrosine // Synonymes: H-Tyr(2-azidoethyl)-OH, (S)-2-amino-3-(4-(2-azidoethoxy)phenyl)propanoic acid, Azidoethoxyphenylalanine, AePhe, H-L-Phe(4-(2-azidoethoxy))-OH,(2S)-2-amino-3-[4-(2-azidoethoxy)phenyl]propanoic acid, H-Phe(4-(2-azidoethoxy))-OH, p2AzY, 4-(2-azidoetho
- n° Art.:HAA9310
- n° CAS:1570523-47-5
- Formule:C11H14N4O3
- Storage temperature:2-8°C
- Masse moléculaire:250,26 g/mol
- Pureté:min. 98%
- Pureté Énantiomérique:min. 99,7%
from 120,00 €
description
This unnatural Tyrosine derivative bears an azidoethyl substitution as reactive handle e.g. for biorthogonal conjugations, via a Cu(I)-catalyzed 1,3-dipolar Click cycloaddition with alkynes. Furthermore, this NCAA can be incorporated into proteins and used as an IR vibrational reporter and Click-chemistry partner.
This product is also available as HCl salt. Fore product details see HAA9215.
references
The genetic incorporation of thirteen novel non-canonical amino acids; A. Tuley, Y.-S. Wang, X. Fang, Y. Kurra, Y. H. Rezenom, W. R. Liu; Chem. Commun. 2014; 50: 2673-2675. https://doi.org/10.1039/C3CC49068H
Azidoethoxyphenylalanine as a Vibrational Reporter and Click Chemistry Partner in Proteins; E. M. Tookmanian, C. M. Phillips-Piro, E. E. Fenlon, S. H. Brewer; Chem. Eur. J. 2015; 21(52): 19096-19103. https://doi.org/10.1002/chem.201503908
Synthesis and Incorporation of Unnatural Amino Acids To Probe and Optimize Protein Bioconjugations; J. C. Maza, J. R. McKenna, B. K. Raliski, M. T. Freedman, D. D. Young; Bioconjugate Chem. 2015; 26(9): 1884-1889. https://doi.org/10.1021/acs.bioconjchem.5b00424
Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids; J. R. Frost, Z. Wu, Y. C. Lam, A. E. Owens, R. Fasan; Org. Biomol. Chem. 2016; 24: 5803-5812. https://doi.org/10.1039/C6OB00192K
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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