Biotin-Pen-CBT

Nom chimique: N-(5-((2-cyano-6-benzothiazolyl)amino)-5-oxopentyl)-biotin // Synonymes: N-(2-cyanobenzo[d]thiazol-6-yl)-5-biotinyl-pentanamide, CBT-pentanoyl-biotin, Biotin-pentanoyl-CBT, Biotin-pentanoyl-cyanobenzothiazole, Biotin-C5-CBT, BPCBT, CBTP-Biotin

  • n° Art.:RL-4240
  • n° CAS:2550397-17-4
  • Formule:C23H28N6O3S2
  • Storage temperature:-20°C
  • Masse moléculaire:500,64 g/mol

from 200,00 €

Grouped product items
Nombre Unité de vente Prix SKU Disponibilité
25 mg
200,00 €
RL-4240.0025
sur demande
100 mg
600,00 €
RL-4240.0100
sur demande
description

The site-specific labeling of proteins by chemical reactions has gained increased interest for the investigation of cellular processes. In this regard, the CBT-Cys „click“ condensation reaction has found wide applicability in recent years. The reaction is highly biocompatible and controllable and runs under physiological conditions. It is based on the condensation between an N-terminal L- or D-Cysteine with the cyano group of CBT.

references

N, S-Double Labeling of N-Terminal Cysteines via an Alternative Conjugation Pathway with 2-Cyanobenzothiazole; W. Wang, J. Gao; J. Org. Chem. 2020, 85(3): 1756–1763. https://doi.org/10.1021/acs.joc.9b02959


Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2; J. T. Hampton, T. J. Lalonde, J. M. Tharp, Y. Kurra, Y. R. Alugubelli, C. M. Roundy, G. L. Hamer, S. Xu, W. R. Liu; ACS Chem. Biol. 2022, 17(10): 2911–2922. https://doi.org/10.1021/acschembio.2c00565


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