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Mmsb-OH Linker
Nom chimique: 2-((4-(hydroxymethyl)-3-methoxyphenyl)sulfinyl)acetic acid // Synonymes: 2-methoxy-4-methylsulfinylbenzyl alcohol, safety catch Mmsb-OH, 2-((4-(hydroxymethyl)-3-methoxyphenyl)sulfinyl)acetic acid, 2-Methoxy-4-carboxymethylsulfinyl benzyl alcohol
- n° Art.:RL-3895
- n° CAS:1234793-64-6
- Formule:C10H12O5S
- Storage temperature:2-8°C
- Masse moléculaire:244,26 g/mol
from 375,00 €
description
This building block may be immobilized via the carboxy function. The benzyl alcohol function may be used to build up a structure that has a hydroxy group upon release. The hydroxyl group is released by reduction of the sulfoxide, followed by acidolysis with TFA.
references
A new safety-catch protecting group and linker for solid-phase synthesis; S. Thennarasu, C.-F. Liu; Tetrahedron Lett. 2010; 51(24): 3218-3220. https://doi.org/10.1016/j.tetlet.2010.04.047
Solid-Phase Peptide Synthesis Using a Four-Dimensional (Safety-Catch) Protecting Group Scheme; S. Noki, E. Brasil. H. Zhang, T. Bruckdorfer, B. G. de la Torre, F. Albericio; J. Org. Chem. 2022; 87: 9443-9453. https://doi.org/10.1021/acs.joc.2c01056
Semipermanent C-Terminal Carboxylic Acid Protecting Group: Application to Solubilizing Peptides and Fragment Condensation; M. Paradis-Bas, J. Tulla-Puche, F. Albericio; Org. Lett. 2015; 17(2): 294–297. https://doi.org/10.1021/ol5033943
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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