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Smoc-L-His-OH
Nom chimique: (((2,7-disulfo-9H-fluoren-9-yl)methoxy)carbonyl)-L-histidine potassium salt // Synonymes: potassium (S)-9-((((1-carboxy-2-(1H-imidazol-4-yl)ethyl)carbamoyl)oxy)methyl)-9H-fluorene-2,7-disulfonate, Smoc-His-OH
- n° Art.:SAA1140
- n° CAS:2442552-74-9 (net)
- Formule:C21H17K2N3O10S2
- Storage temperature:2-8°C
- Masse moléculaire:613,69 g/mol
from 40,00 €
description
Building blocks for aqueous solid-phase peptide synthesis (ASPPS). The 2,7-disulfo-9-fluorenylmethoxycarbonyl (Smoc) protecting group allows peptide synthesis using water instead of organic solvents – finally combining sustainability with cost optimization. The building blocks possess significant stability in basic aqueous solutions, but are easily losing their amino terminal protection upon mild treatment with particular water-soluble bases, e.g. NaOH, NH3, piperazine or ethanolamine. For ASPPS, a water-compatible resin, e.g. Tentagel, ChemMatrix, is required.
references
Method for peptide synthesis and apparatus for carrying out a method for solid phase synthesis of peptides; S. Knauer, T. M. L. Roese, O. Avrutina, H. Kolmar, C. Uth; 2016, WO 2016 050764.
Sustainable Peptide Synthesis Enabled by a Transient Protecting Group; S. Knauer, N. Koch, C. Uth, R. Meusinger, O. Avrutina, H. Kolmar; Angew. Chem. Int. Ed. 2020; 59(31): 12984-12990. https://doi.org/10.1002/anie.202003676.
Improved method for preparing peptides; S. Knauer; WO 2019 101939.
Method for preparing peptides; S. Knauer; WO 2019 101940.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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