Welcome to Iris Biotech
For better service please confirm your country and language we detected.
For better service please confirm your country and language we detected.
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying through a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.
Continue to Iris Biotech GmbHSend request to US distributorChemical name: N-alpha-(t-Butyloxycarbonylamino)-1-adamantyl-L-alanine // Synonyms: (2S)-3-((1s,3R)-adamantan-1-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid, Boc-Ala(Adamantyl)-OH, (S)-Boc-1-adamantyl-alanine, Boc-Ala(Adamantyl)-OH
from €750.00
The highly lipophilic, symmetrical adamantly motif is reported for its hydrophobic bulk and spherical shape, proposed by modelling to favor hydrophobic contacts in protein binding pockets. Thus, this non-natural adamantanyl alanine building block can be used for structure-activity-relationship studies. Furthermore, adamantane is part of various medicinally important compounds.
Synthesis and Biological Properties of Enkephalin-like Peptides Containing Adamantylalanine in Position 4 and 5; K. Q. Do, R. Schwyzer; Helv. Chim. Acta 1981; 64(7): 2084-2089. https://doi.org/10.1002/hlca.19810640713.
Structure activity of C-terminal modified analogs of Ac-CCK-7; J. W. Tilley, W. Danho, S.-J. Shiuey, I. Kulesha, R. Sarabu, J. Swistok, R. Makofske, G. L. Olson, E. Chiang, V. K. Rusieckt, R. Wagner, J. Michalewsky, J. Triscari, D. Nelson, F. Y. Chiruzzo, S. Weatherford; Int. J. Pept. Res. 1992; 39(4): 322-336. https://doi.org/10.1111/j.1399-3011.1992.tb01592.x.
An Adamantyl Amino Acid Containing Gramicidin S Analogue with Broad Spectrum Antibacterial Activity and Reduced Hemolytic Activity; V. V. Kapoerchan, A. D. Knijnenburg, M. Niamat, E. Spalburg, A. J. de Neeling, P. H. Nibbering, R. H. Mars-Groenendijk, D. Noort, J. M. Otero, A. L. Llamas-Saiz, M. J. van Raaij, G. A. van der Marel, H. S. Overkleeft, M. Overhand; Chem. Eur. J. 2010; 16(40): 12174-12181. https://doi.org/10.1002/chem.201001686.
Tuning hydrophobicity of highly cationic tetradecameric Gramicidin S analogues using adamantane amino acids; A. D. Knijnenburg, V. V. Kapoerchan, E. Spalburg, A. J. de Neeling, R. H. Mars-Groenendijk, D. Noort, G. A. van der Marel, H. S. Overkleeft, M. Overhand; Bioorg. Med. Chem. 2010; 18(23): 8403-8409. https://doi.org/10.1016/j.bmc.2010.09.018.
Structure-Based Design of b5c Selective Inhibitors of Human Constitutive Proteasomes; B.-T. Xin, G. de Bruin, E. M. Huber, A. Besse, B. I. Florea, D. V. Filippov, G. A. van der Marel, A. F. Kisselev, M. van der Stelt, C. Driessen, M. Groll, H. S. Overkleeft; J. Med. Chem. 2016; 59(15): 7177-7187. https://doi.org/10.1021/acs.jmedchem.6b00705.
Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib; G. de Bruin, E. D. Mock, S. Hoogendoorn, A. M. C. H. van den Nieuwendijk, J. Mazurek, G. A. van der Marel, B. I. Florea, H. S. Overkleeft; Chem. Commun. 2016; 52: 4064-4067. https://doi.org/10.1039/C6CC01156J.
Please send me more information about