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Fmoc-L-2AHe-OH
Chemical name: (S)-N-(9-Fluorenylmethyloxycarbonyl)-2-amino-hexadecanoic acid // Synonyms: (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)hexadecenoic acid, Fmoc-L-2-aminohexadecanoic acid, Fmoc-L-2-aminopalmitic acid, Fmoc-2Ahe-OH
- Product code:FAA8540
- CAS No.:193885-60-8
- Formula:C31H43NO4
- Storage temperature:2-8°C
- Molecular weight:493.68 g/mol
- Enantiomeric Purity:90%
from €300.00
description
Fatty amino acids improve the pharmacokinetic & pharmacologic properties of peptide APIs and other biopharmaceuticals. The most prominent block busters are Liraglutide and Semaglutide. Their lifetime in serum is drastically improved as the fatty acid residue helps to bind temporarily to serum albumin. This conjugation enhances stability towards proteolytic degradation and serves as drug delivery technique.
references
Diastereoselective alkylation of Schiff bases for the synthesis of lipidic unnatural Fmoc-protected alpha-amino acids; A. M. Papinin, E. Nardi, F. Nuti, J. Uziel, M. Ginanneschi, M. Chelli, A. Brandi; Eur. J. Org. Chem. 2002; 16: 2736-2741. https://doi.org/10.1002/1099-0690(200208)2002:16<2736::AID-EJOC2736>3.0.CO;2-5
Synthesis of unnatural lipophilic N-(9H-fluoren-9-ylmethoxy)carbonyl-substituted alpha-amino acids and their incorporation into cyclic RGD-peptides. A structure-activity study; M. Koppitz, M. Huenges, R. Gratias, H. Kessler, S. L. Goodman, A. Jonczyk; Helv. Chim. Acta 1997; 80(4): 1280-1300. https://doi.org/10.1002/hlca.19970800423
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