Welcome to Iris Biotech
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Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying through a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.
Continue to Iris Biotech GmbHSend request to US distributorChemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-beta-anthraniloyl-(2-formamido)-L-alanine // Synonyms: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-formamidophenyl)-4-oxobutanoic acid, Fmoc-Kyn(CHO)-OH, Fmoc-L-Kynurenine(CHO)-OH, Fmoc-Kyn(CHO)-OH
from €375.00
The non-proteinogenic amino acid Kynurenine (Kyn) is a known oxidation product of tryptophan. In cells, this process may be caused by reactive oxygen species (ROS). Such changes can lead to altered protein structure and function causing either degradation or accumulation/aggregation linked to the pathogenesis of several diseases. Our Fmoc-protected Kyn allows to synthesize model peptides for functional and structural studies.
Besides, Kyn is also part of Daptomycin (trade name Cubicin), an effective lipopeptide for the treatment of infections caused by antibiotic-resistant gram-positive pathogens.
Effective synthesis of kynurenine-containing peptides via on-resin ozonolysis of tryptophan residues: synthesis of cyclomontanin B; C. T. T. Wong, H. Y. Lam, X. Li; Org. Biomol. Chem. 2013; 11: 7616-7620. https://doi.org/10.1039/C3OB41631C.
Total Synthesis of Daptomycin by Cyclization via Chemoselective Serine Ligation; H. Y. Lam, Y. Zhang, H. Liu, J. Xu, C. T. T. Wong, C. Xu, X. Li; J. Am. Chem. Soc. 2013; 135(16): 6272-6270. https://doi.org/10.1021/ja4012468.
Synthesis of peptides containing 5‐hydroxytryptophan, oxindolylalanine, N‐formylkynurenine and kynurenine; T. Todorovski, M. Fedorova, L. Hennig, R. Hoffmann; J. Pept. Sci. 2011; 17: 256-262. https://doi.org/10.1002/psc.1322.
Mass spectrometric characterization of peptides containing different oxidized tryptophan residues; T. Todorovski, M. Fedorova, R. Hoffmann; J. Mass. Spectrom. 2011; 46: 1030-1038. https://doi.org/10.1002/jms.1984.