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Fmoc-L-Dab(Boc-Cys(Trt))-OH
Chemical name: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-((R)-2-((tert-butoxycarbonyl)amino)-3-(tritylthio)propanamido)butanoic acid // Synonyms: Fmoc-Dab(Boc-Cys(Trt))-OH
- Product code:FAA9325
- CAS No.:2968514-52-3
- Formula:C46H47N3O7S
- Storage temperature:2-8°C
- Molecular weight:785.96 g/mol
from €450.00
description
Bicyclic peptides have high potential as next generation pharmaceuticals, e.g., to disrupt the difficult to target interactions between proteins. For controlled cyclization, selective reactivities are required. Our 1,2-aminothiol and 1,3-thiazole building blocks yield the ideal combination for this purpose, and, in addition, are compatible with SPPS. Besides, when used N-terminally, 1,2-aminothiols are useful for connecting peptide fragments by native chemical ligation (NCL).
references
A biocompatible stapling reaction for in situ generation of constrained peptides; R. Morewood, C. Nitsche; Chem. Sci. 2021; 12: 669-674. https://doi.org/10.1039/D0SC05125J
Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents; A. Istrate, M. Geeson, C. Navo, B. Sousa, M. Marques, R. Taylor, T. Journeaux, S. Oehler, M. Mortensen, M. Deery, A. Bond, F. Corzana, G. Jiménez-Osés, G. Bernardes; JAmChemSoc. 2022; 144: 10396-10406. https://doi.org/10.1021/jacs.2c02185
Recent advances in N- and C-terminus cysteine protein bioconjugation; R. Spears, V. Chudasama; CurrOpinChemBiol. 2023; 75: 102306. https://doi.org/10.1016/j.cbpa.2023.102306
Biocompatible and Selective Generation of Bicyclic Peptides; S. Ullrich, J. George, A. Coram, R. Morewood, C. Nitsche; AngewChemIntEd. 2022; 61: e202208400. https://doi.org/10.1002/anie.202208400
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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