Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Quick contact
Please send me more information about
Biotin-DBCO
Chemical name: (3aS,4S,6aR)-N-[3-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide // Synonyms: Biotin-Dibenzocyclooctyne
- Product code:LS-4270
- CAS No.:1418217-95-4
- Formula:C28H30N4O3S
- Storage temperature:-20°C
- Molecular weight:502.63 g/mol
from €400.00
description
This biotin derivative bears a terminal DBCO group. It can be used to prepare various biotinylated conjugates via Click Chemistry. Biotin can be subsequently detected e.g. via streptavidin or avidin. DBCO alkynes allow to perform click reactions with azide-modified targets without the use of heavy metal catalysis via a strain-promoted azide-alkyne click reaction (SPAAC).
references
High-Throughput “FP-Tag” Assay for the Identification of Glycosyltransferase Inhibitors; Z. Gao, O. G. Ovchinnikova, B.-S. Huang, F. Liu, D. E. Williams, R. J. Andersen, T. L. Lowary, C. Whitfield, S. G. Withers; J. Am. Chem. Soc. 2019; 141(6): 2201-2204. https://doi.org/10.1021/jacs.8b10940.
Site-Specific Dual Functionalization of Cysteine Residue in Peptides and Proteins with 2-Azidoacrylates; S. Ariyasu, H. Hayashi, B. Xing, S. Chiba; Bioconjugate Chem. 2017; 28(4): 897-902. https://doi.org/10.1021/acs.bioconjchem.7b00024.
Diazo Groups Endure Metabolism and Enable Chemoselectivity in Cellulo; K. A. Andersen, M. R. Aronoff, N. A. McGrath, R. T. Raines; J. Am. Chem. Soc. 2015; 137(7): 2412-2415. https://doi.org/10.1021/ja5095815.
Do you need further information about this product?
get in contact
Brochures & Flyers
We found other products you might like!
