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Biotin-DBCO
Chemical name: (3aS,4S,6aR)-N-[3-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide // Synonyms: Biotin-Dibenzocyclooctyne
- Product code:LS-4270
- CAS No.:1418217-95-4
- Formula:C28H30N4O3S
- Storage temperature:-20°C
- Molecular weight:502.63 g/mol
from €400.00
description
This biotin derivative bears a terminal DBCO group. It can be used to prepare various biotinylated conjugates via Click Chemistry. Biotin can be subsequently detected e.g. via streptavidin or avidin. DBCO alkynes allow to perform click reactions with azide-modified targets without the use of heavy metal catalysis via a strain-promoted azide-alkyne click reaction (SPAAC).
references
High-Throughput “FP-Tag” Assay for the Identification of Glycosyltransferase Inhibitors; Z. Gao, O. G. Ovchinnikova, B.-S. Huang, F. Liu, D. E. Williams, R. J. Andersen, T. L. Lowary, C. Whitfield, S. G. Withers; J. Am. Chem. Soc. 2019; 141(6): 2201-2204. https://doi.org/10.1021/jacs.8b10940.
Site-Specific Dual Functionalization of Cysteine Residue in Peptides and Proteins with 2-Azidoacrylates; S. Ariyasu, H. Hayashi, B. Xing, S. Chiba; Bioconjugate Chem. 2017; 28(4): 897-902. https://doi.org/10.1021/acs.bioconjchem.7b00024.
Diazo Groups Endure Metabolism and Enable Chemoselectivity in Cellulo; K. A. Andersen, M. R. Aronoff, N. A. McGrath, R. T. Raines; J. Am. Chem. Soc. 2015; 137(7): 2412-2415. https://doi.org/10.1021/ja5095815.
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Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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