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H-O2Oc-O2Oc-OH
Chemical name: 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan-1-oic acid // Synonyms: (AEEA)2, AEEA-AEEA, H-Ado-Ado-OH, H-Adoa-Adoa-OH, 8-amino-3,6-dioxaoctanoic acid dimer, H-AEEA-AEEA-OH
- Product code:PEG1221
- CAS No.:1143516-05-5
- Storage temperature:2-8°C
- Formula:C12H24N2O7
- Molecular weight:308.33 g/mol
- Purity :min. 99%
from €150.00
description
AEEA-AEEA residue is used to acylate Lysine side-chain in Insulin and other peptides to increase clearance time and protease resistance of peptides in vivo.
This compound is also used as a hydrophylic linker
references
Christensen, Caspar; Severinsen, Rune; Petersen, Anders Klarskov; Kidal, Steffen; Jessen, Claus U.; Madsen,Peter; Valore, Henrik; Tagmose, Tina Moeller; Soerensen, Jan Lindy PCT Int. Appl. (2010), WO 2010029159 A1;
Madsen, Peter; Kjeldsen, Thomas Boerglum; Hoeg-Jensen, Thomas; Jakobsen, Palle; Tagmose, Tina Moeller; Glendorf, Tine; Kodra, Janos Tibor; Garibay, Patrick William PCT Int. Appl. (2009), WO 2009115469 A1.
WO2006097537A2.
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