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H-L-His(Clt)-2CT Resin
Chemical name: H-L-His(Clt)-2-chlorotrityl resin // Synonyms: H-His(Clt)-2CT Resin
- Product code:RAA1093
- Storage temperature:-20°C
- Particle size :100-200 mesh
- DVB crosslinking :1% DVB
- Loading:> 0.4 mmol/g
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description
The Clt (2-chlorotrityl) protecting group is more stable than the commonly used Trt group and is being deprotected with 95%TFA in dichloromethane. The main application is in peptide synthesis, whenever certain treatments and modifications of the peptide are being applied, where the standard His(Trt) protection is too labile.
references
Aletras A., Barlos K. et al; Int. J. Pept. Protein Res. 1995; 45(5): 488-496.
Barlos K. et al; Int. J. Pept. Protein Res. 1991; 38(6): 555-561.
Sarah L.M. et al, in „Fmoc Solid Phase Synthesis. A practical approach“, Ed.: Chan W.C., White P.D. Oxford University Press 2000, page 177.
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