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DBCO-Sulfo-PEG(4)-NH2
Chemical name: Dibenzoazacyclooctyne-tetra(ethylene glycol)amine // Synonyms: DBCO-Sulfo-PEG(4)-amine
- Product code:RL-2421
- CAS No.:2055198-05-3
- Formula:C32H42N4O10S
- Molecular weight:674.76 g/mol
from €390.00
description
Cyclooctyne linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with azides and tetrazines. The amine function can be used to form amid bonds or for alkylation via reductive amination. The sulfo group in the linker provides additional stability and temperature resistance compared to simple, linear PEG based chains.
references
Simon et al.; Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chem. 2012; 23(2): 279.
Zeng et al.; 64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Nano. 2012; 6(6): 5209.
Arumugam et al.; [18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg. Med. Chem. Lett. 2011; 21: 6987.
Campbell-Verduyn et al.; Strain-Promoted Copper-Free Click Chemistry for 18F Radiolabeling of Bombesin. Angew. Chem. Int. Ed. 2011; 50: 11117.
Debets et al.; Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. Chem. Commun. 2010; 46: 97.
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