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Mal-SS-COOH
Chemical name: 3-((2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethyl)disulfanyl)propanoic acid
- Product code:RL-4090
- CAS No.:2128735-24-8
- Formula:C12H16N2O5S2
- Storage temperature:2-8°C
- Molecular weight:332.39 g/mol
from €300.00
description
Disulfide-Based Linker bearing a maleimide and carboxylic acid as functional group for crosslinking. The disulfide bond can be cleaved by reduction.
references
Linker Technologies for Antibody-Drug Conjugates; B. Nolting; Antibody-Drug Conjugates L. Ducry 2013; 1045: 71-100. https://doi.org/10.1007/978-1-62703-541-5_5
Current ADC linker chemistry; N. Jain, S. W. Smith, S. Ghone, B. Tomczuk; Pharm. Res. 2015; 32: 3526-3540. https://doi.org/10.1007/s11095-015-1657-7
Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry; J. R. McCombs, S. C. Owen; AAPS J. 2015; 17(2): 339-351. https://doi.org/10.1208/s12248-014-9710-8
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