Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Quick contact
Please send me more information about
Gly-CBT*HCl
Chemical name: 2-Amino-N-(2-cyano-6-benzothiazolyl)acetamide hydrochloride // Synonyms: CBT-Glycine, CBTG, Glycine-cyanobenzothiazole, Cyanobenzothiazolyl-glycine, 2-Amino-N-(2-cyanobenzo[D]thiazol-6-yl) acetamide, 2-amino-N-(2-cyano-1,3-benzothiazol-6-yl) acetamide,CBT-Gly
- Product code:RL-4220
- CAS No.:1207457-28-0 net
- Formula:C10H8N4OS*HCl
- Storage temperature:-20°C
- Molecular weight:232.26*36.45 g/mol
from €300.00
description
The site-specific labeling of proteins by chemical reactions has gained increased interest for the investigation of cellular processes. In this regard, the CBT-Cys „click“ condensation reaction has found wide applicability in recent years. The reaction is highly biocompatible and controllable and runs under physiological conditions. It is based on the condensation between an N-terminal L- or D-Cysteine with the cyano group of CBT.
references
A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins; H. Ren, F. Xiao, K. Zhen, Y.P. Kim, H. Xie, Z. Xia, J. Rao; Angew. Chem. Int. Ed. 2009, 48: 9658-9662. https://doi.org/10.1002/anie.200903627
Genetically Encoded 1,2-Aminothiols Facilitate Rapid and Site-Specific Protein Labeling via a Bio-orthogonal Cyanobenzothiazole Condensation; J. Am. Chem. Soc. 2011, 133(30): 11418–11421. https://doi.org/10.1021/ja203111c
Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole; P. Wang, C.J. Zhang, G. Chen, Z. Na, S. Q. Yao, H. Sun; Chem. Commun. 2013, 49: 8644-8646. https://doi.org/10.1039/C3CC43566K
Sequence-Specific 2-Cyanobenzothiazole Ligation; C. P. Ramil, P. An, Z. Yu, Q. Lin; J. Am. Chem. Soc. 2016, 138 (17): 5499–5502. https://doi.org/10.1021/jacs.6b00982
Peptide cleavage induced assembly enables highly sensitive electrochemiluminescence detection of protease activity; M. Cheng, J. Zhuo, X. Zhou, D. Xing; Sens. Actuators B Chem. 2018, 262: 516-52. https://doi.org/10.1016/j.snb.2018.01.191
Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long-term treatment of inflammatory arthritis; Y. Gao, D. Vogus, Z. Zhao, W. He, V. Krishnan, J. Kim, Y. Shi, A. Sarode, A. Ukidve, S. Mitragotri; Bioeng. Transl. Med. 2022, 7: e10245. https://doi.org/10.1002/btm2.10245
Affinity Bioorthogonal Chemistry (ABC) Tags for Site-Selective Conjugation, On-Resin Protein-Protein Coupling, and Purification of Protein Conjugates; S. L. Scinto, T. R. Reagle, J. M. Fox; Angew. Chem. Int. Ed. 2022, 61: e202207661. https://doi.org/10.1002/anie.202207661
Optimized molecular design of PET probe for the visualization of ã-glutamyltranspeptidase activity in tumors; X. Wang, D. Gao, C. Lu, M. Xie, J. Lin, L. Qiu; New J. Chem. 2022, 46: 10219-10228. https://doi.org/10.1039/D2NJ01688E
* Disclaimer
We refer to our general terms and conditions.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
Do you need further information about this product?
get in contact
We found other products you might like!
