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REM Resin
Chemical name: Acryloylmethyl polystyrene
- Product code:SR-1036
- Storage temperature:2-8°C
- Particle size :100-200 mesh
- DVB crosslinking :1% DVB
- Loading:0.5-1.3 mmol/g
from €100.00
description
Resin with immobilized acrylic acid serves as support for the solid phase synthesis of tertiary amines. Immobilization of a primary or secondary amine via Michael addition is followed by quaternization with the appropriate alkyl halide. beta-Elimination yields the tertiary amine.
references
R. Brown et al.; J. Am. Chem. Soc. 1997; 119: 3288.
J. Cattney et al.; Bioorg. Med. Chem. Lett. 1999; 9: 1323.
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