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N3-HABA*DCHA (2S)
Chemical name: (S)-4-azido-2-hydroxybutyric acid dicyclohexalamine // Synonyms: Azido hydroxybutyric acid DCHA salt, (2S)-4-azido-2-hydroxybutanoic acid dicyclohexylamine, N3-HABA
- Product code:HAA3175
- CAS No.:959148-55-1
- Formula:C4H7N3O3*C12H23N
- Storage temperature:2-8°C
- Molecular weight:145,12*181,32 g/mol
- Purity :min. 99%
- Enantiomeric Purity:min. 99,7%
from €80.00
description
This azide-containing chiral alpha-hydroxybutyric acid can be used as a building block for the construction of aminoglycoside antibiotics. Further modification using Click-chemistry (CuAAC) can be performed.
references
Development of Novel Aminoglycoside (NB54) with Reduced Toxicity and Enhanced Suppression of Disease-Causing Premature Stop Mutations; I. Nudelman, A. Rebibo-Sabbah, M. Cherniavsky, V. Belakhov, M. Hainrichson, F. Chen, J. Schacht, D. S. Pilch, T. Ben-Yosef, and T. Baasov; J. Med. Chem. 2009; 52: 2836-2845. https://doi.org/10.1021/jm801640k.
Aminoglycoside antibiotics; F. Liu, G. Myers; 2018; WO2019079706A1
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