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Alkyne-myristic acid
Chemical name: 13-Tetradecynoic acid // Synonyms: Tetradec-13-ynoic acid
- Product code:RL-2055
- CAS No.:82909-47-5
- Formula:C14H24O2
- Storage temperature:2-8°C
- Molecular weight:224,34 g/mol
from €400.00
description
Linker for bioconjugation via Click reaction. Protein acylation with this compound leads to rapid, selective and robust fluorescent detection with chemical reporters.
references
Robust fluorescent detection of protein fatty-acylation with chemical reporters; G. Charron, M. M. Zhang, J. S. Yount, J. Wilson, A. S. Raghavan, E. Shamir and H. C. Hang; J Am Chem Soc 2009; 131: 4967-75. https://doi.org/10.1021/ja810122f
Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry; M. C. Yap, M. A. Kostiuk, D. D. Martin, M. A. Perinpanayagam, P. G. Hak, A. Siddam, J. R. Majjigapu, G. Rajaiah, B. O. Keller, J. A. Prescher, P. Wu, C. R. Bertozzi, J. R. Falck and L. G. Berthiaume; J Lipid Res 2010; 51: 1566-80. https://doi.org/10.1194/jlr.D002790
SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine; H. Jiang, S. Khan, Y. Wang, G. Charron, B. He, C. Sebastian, J. Du, R. Kim, E. Ge, R. Mostoslavsky, H. C. Hang, Q. Hao and H. Lin; Nature 2013; 496: 110-3. https://doi.org/10.1038/nature12038
The biology and enzymology of protein N-myristoylation; T. A. Farazi, G. Waksman and J. I. Gordon; J Biol Chem 2001; 276: 39501-4. https://doi.org/10.1074/jbc.R100042200
The growing impact of click chemistry on drug discovery; H. C. Kolb and K. B. Sharpless; Drug Discov Today 2003; 8: 1128-37. https://doi.org/10.1016/S1359-6446(03)02933-7
Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry; J. F. Lutz and Z. Zarafshani; Adv Drug Deliv Rev 2008; 60: 958-70. https://doi.org/10.1016/j.addr.2008.02.004
Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives; A. Vila, K. A. Tallman, A. T. Jacobs, D. C. Liebler, N. A. Porter and L. J. Marnett; Chemical research in toxicology 2008; 21: 432-44. https://doi.org/10.1021/tx700347w
Chemical Reporters of Protein Acylation; H. C. N. Y. Hang, NY, US), Charron, Guillaume (NEW YORK, NY, US), Wilson, John P. (NEW YORK, NY, US), Raghavan, Anuradha (NEW HAVEN, CT, US), Zhang, Mingzi (NEW YORK, NY, US), Yang, Yu-ying (STAMFORD, CT, US), Rangan, Kavita (NEW YORK, NY, US), Tsou, Lun K. (NEW YORK, NY, US), Yount, Jacob (BROOKLYN, NY, US); 2010.
Chemical reporters for exploring protein acylation; E. Thinon and H. C. Hang; Biochem Soc Trans 2015; 43: 253-61. https://doi.org/10.1042/BST20150004
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