Fmoc-3-Amino-adamantane-1-carboxylic acid

Chemischer Name: 3-(9-Fluorenylmethyloxycarbonyl)-amino-adamantane-1-carboxylic acid // Synonyme: (1r,3r)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)adamantane-1-carboxylic acid, 3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)adamantane-1-carboxylic acid

  • Art-Nr.:FAA8505
  • CAS Nr.:875211-10-2
  • Formel:C26H27NO4
  • Lagertemperatur:2-8°C
  • Molare Masse:417,51 g/mol

Ab 450,00 €

Gruppiert Produkte - Artikel
Anzahl Verpackungsgröße Preis SKU Warenverfügbarkeit
1 g
450,00 €
FAA8505.0001
<10 Arbeitstage
5 g
1.800,00 €
FAA8505.0005
<10 Arbeitstage
description

The highly lipophilic, symmetrical adamantly motif is reported for its hydrophobic bulk and spherical shape, proposed by modelling to favor hydrophobic contacts in protein binding pockets. Thus, this non-natural adamantane g-amino acid building block can be used for structure-activity-relationship studies. Furthermore, adamantane is part of various medicinally important compounds.


references

Conjugation to Polymeric Chains of Influenza Drugs Targeting M2 Ion Channels Partially Restores Inhibition of Drug-Resistant Mutants; A. M. Larson, J. Chen, A. M. Klibanov; J. Pharm. Sci. 2013; 102(8): 2450-2459. https://doi.org/10.1002/jps.23644.


Lipophilic Oligopeptides for Chemo- and Enantioselective Acyl Transfer Reactions onto Alcohols; C. E. Müller, D. Zell, R. Hrdina, R. C. Wende, L. Wanka, S. M. M. Schuler, P. R. Schreiner; J. Org. Chem. 2013; 78(17): 8465-8484. https://doi.org/10.1021/jo401195c.


Exploring N-Arylsulfonyl-L-proline Scaffold as a Platform for Potent and Selective anb1 Integrin inhibitors; N. I. Reed, Y.-Z. Tang, J. McIntosh, Y. Wu, K. S. Molnar, A. Civitavecchia, D. Sheppard, W. F. DeGrado, H. Jo; ACS Med. Chem. Lett. 2016; 7(10): 902-907. https://doi.org/10.1021/acsmedchemlett.6b00196.

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