Fmoc-L-Lys(Boc)-MPPA

Chemischer Name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-t-butyloxycarbonyl-L-lysine-3-(4-oxymethylphenoxy)propionic acid // Synonyme: 3-(4-(((N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysyl)oxy)methyl)phenoxy)propanoic acid,N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine-[4 -(2-carboxyethoxy)phenyl]methyl ester, Fmoc-Lys(Bo

  • Art-Nr.:LW01202
  • CAS Nr.:1356004-85-7
  • Formel:C36H42N2O9
  • Lagertemperatur:2-8°C
  • Molare Masse:646,74 g/mol

Ab 95,00 €

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Anzahl Verpackungsgröße Preis SKU Warenverfügbarkeit
1 g
95,00 €
LW01202.0001
11-20 Arbeitstage
5 g
375,00 €
LW01202.0005
11-20 Arbeitstage
description

This Fmoc-amino acid-MPPA linker serves as precursor for the linkage to e.g. aminomethyl supports by standard coupling procedures. By this method, a low (max 0.5%) and reproducible epimerization level of the C-terminal amino acid in your peptide is guaranteed.


references

Improved approach for anchoring Nalpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis; F. Albericio, G. Barany; Int. J. Peptide. Protein. Res. 1985; 26(1): 92-97. https://doi.org/10.1111/j.1399-3011.1985.tb03182.x.


Amino acid derivatives used as agents bonding to a solid support; NeoMPS S.A. 2005; French Patent Application FR 0402973, International Patent Application WO2005/095332.

Convergent chemo-enzymatic synthesis of mannosylated glycopeptides; targeting of putative vaccine candidates to antigen presenting cells; J. D. McIntosh, M. A. Brimble, A. E. S. Brooks, P. Rod Dunbar, R. Kowalczyk, Y. Tomabechi, A. J. Fairbanks; Chem. Sci. 2015; 6: 4636-4642. https://doi.org/10.1039/C5SC00952A.


Synthesis of a dicarba analogue of human b-defensin-1 using a combined ring closing metathesis—native chemical ligation strategy; A. M. Heapy, G. M. Williams, J. D. Fraser, M. A. Brimble; Org. Lett. 2012; 14(3): 878-881. https://doi.org/10.1021/ol203407z. 

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