Smoc-L-Glu(OtBu)-OH

Chemischer Name: (((2,7-disulfo-9H-fluoren-9-yl)methoxy)carbonyl)-L-glutamic-acid-gamma-t-butyl-ester potassium salt // Synonyme: potassium (S)-9-((((4-(tert-butoxy)-1-carboxy-4-oxobutyl)carbamoyl)oxy)methyl)-9H-fluorene-2,7-disulfonate,(S)-5-(tert-butoxy)-2-((((2,7-disulfo-9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-oxopentanoi c acid potassium salt, Smoc-Glu(OtBu)-OH

  • Art-Nr.:SAA1120
  • CAS Nr.:2442552-71-6 (net)
  • Lagertemperatur:2-8°C
  • Formel:C24H25K2NO12S2
  • Molare Masse:661,78 g/mol

Ab 70,00 €

Gruppiert Produkte - Artikel
Anzahl Verpackungsgröße Preis SKU Warenverfügbarkeit
5 g
70,00 €
SAA1120.0005
<10 Arbeitstage
10 g
120,00 €
SAA1120.0010
<10 Arbeitstage
description

Building blocks for aqueous solid-phase peptide synthesis (ASPPS). The 2,7-disulfo-9-fluorenylmethoxycarbonyl (Smoc) protecting group allows peptide synthesis using water instead of organic solvents – finally combining sustainability with cost optimization. The building blocks possess significant stability in basic aqueous solutions, but are easily losing their amino terminal protection upon mild treatment with particular water-soluble bases, e.g. NaOH, NH3, piperazine or ethanolamine. For ASPPS, a water-compatible resin, e.g. Tentagel, ChemMatrix, is required.


references

Method for peptide synthesis and apparatus for carrying out a method for solid phase synthesis of peptides; S. Knauer, T. M. L. Roese, O. Avrutina, H. Kolmar, C. Uth; 2016, WO 2016 050764.

Sustainable Peptide Synthesis Enabled by a Transient Protecting Group; S. Knauer, N. Koch, C. Uth, R. Meusinger, O. Avrutina, H. Kolmar; Angew. Chem. Int. Ed. 2020; 59(31): 12984-12990. https://doi.org/10.1002/anie.202003676.

Improved method for preparing peptides; S. Knauer; WO 2019 101939.

Method for preparing peptides; S. Knauer; WO 2019 101940.


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