Blog | Page 52

Improved Synthesis with Dmb-Glycine Dipeptide Building Blocks

Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.

Convenient method of peptide hydrazide synthesis using a new hydrazone resin

Peptide hydrazides can be easily synthesized using a new hydrazone resin, obtained via acylation of aminomethyl polystyrene by Fmoc-hydrazone of pyruvic acid.

Stable Conjugation with Thiols

Maleimide (MAL) reacts rather specific with free thiol groups and forms appropriate conjugates. However, this reaction is slightly reversible, resulting in loss of the conjugation partner.

Amino functions open the maleimido ring structure through hydrolysis with nucleophilc neighboring effect and thus inhibit the undesired release reaction.

Structural Element: Aminoisobutyric Acid and Homologues

Aminoisobutyric acid (Aib) and its homologues are a strong helix promoters in peptide mimetics. Aib-containing model peptides are already used in cancer treatment, antimicrobial peptides and cell penetrating peptides (CPP).

We offer Aib and its homologues positioning the dimethyl fragment either close to the N- or to the C-terminus.

Synthesis of Protected Peptide Amide Fragments with Sieber Resin

Fmoc-Sieber amide resin is an acid-labile carrier for solid phase synthesis of peptide amides. Cleavage with only 1% TFA makes it an ideal carrier for the synthesis of protected peptide fragments in fragment condensation strategies for the synthesis of long peptides.