Blog

4-Methylbenzhydryl-Resins - the Better Wang-Resin alternative

Wang resins are widely used for peptide synthesis. However, certain side reactions, like diketopiperazin formation limit their use. 4-Methylbenzhydryl resin needs more space and leaves less room for this type of side reactions. Standard “Wang-typical” Fmoc/tBu coupling protocols can be applied.

New: Cysteine-Pseudoproline

Pseudoprolines derived from Serine and Threonine have developed to standard building blocks for peptide synthesis since their invention. Now this technology is also available with Cysteine residues, as the corresponding 2,4-dimethoxyphenyl-pseudothiaproline is compatible with standard Fmoc/tBu protocols.

Amino Aldehydes

Aldehydes are between alcohols and carboxylic acids with respect to their oxidation level and show specific reactivity. Therefore they are highly interesting building blocks and intermediates for a large number of very interesting classes of reactions and compounds such as Wittig reaction, formation of secondary alcohols, heterocycles and semiaminals to name only a few.

Bio-Europe Spring 2015

March 9th-11th, 2015
Porte de Versailles, Conference Center
Expo Paris, France

As the springtime counterpart to BIO-Europe, BIO-Europe Spring^® continues the tradition of providing life science companies with high caliber partnering opportunities. Featuring EBD Group’s acclaimed partnering system, partneringONE^®, the event enables delegates to efficiently identify, meet and get partnerships started with companies across the biotech value chain.

In addition to productive partnering, BIO-Europe Spring offers high level workshops, panels, company presentations, and a lively exhibition. The program features executive level panelists who openly share their insight and opinion on many important industry issues. The company presentation tracks provide a forum for innovative start-ups, established biotech companies, and large and midsize pharma to present information on products, partnering opportunities and corporate strategy.

Combined, these elements create an insightful and productive event that will have you coming back year after year.

BIO-Europe Spring is produced by EBD Group, the leading partnering firm for the global biotechnology industry, with the support of the Biotechnology Industry Organization (BIO).

5th Halle Conference on Recombinant Proteins

February 19th-20th, 2015
Deutsche Akademie der Naturforscher Leopoldina
Halle/Saale, Germany

The "Halle Conference on Recombinant Proteins" provides an unique platform for the exchange of latest scientific and technological findings, know-how and expertise between scientists from academia and industry.

Presenters from Pharma industry, Biotech industry and Academia talk about latest developments of protein-based therapeutics covering new formats, modifications, manufacturing, formulation and analytics.

The Conference will take place on February 19^th- 20^th, 2015 at "Deutsche Akademie der Naturforscher Leopoldina".

Non-canonical amino acids in proteins: structural investigations and biocatalysis

February 10th, 2015
DECHEMA-Haus
Frankfurt/Main, Germany

The one-day symposium, organised by the DECHEMA working group on novel bio-production systems, will focus on recent advancements in the production and the application of these artificial proteins.

Linkers for Antibody-Drug Conjugation (ADC)

Cleavable dipeptide linkers like Val-Ala and Val-Cit rely on processes inside the cell to liberate the payload, as they undergo rapid hydrolysis in the presence of lysosomal extracts or purified human cathepsin B.

Photocleavable Cys Protecting Group

This oNv (2-Nitroveratryl) is the latest addition to our repertoire of cysteine protecting groups. It opens new possibilities of orthogonality to the existing strategies for disulfide bridge formation.