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Convenient method of peptide hydrazide synthesis using a new hydrazone resin

Peptide hydrazides can be easily synthesized using a new hydrazone resin, obtained via acylation of aminomethyl polystyrene by Fmoc-hydrazone of pyruvic acid.

Stable Conjugation with Thiols

Maleimide (MAL) reacts rather specific with free thiol groups and forms appropriate conjugates. However, this reaction is slightly reversible, resulting in loss of the conjugation partner.

Amino functions open the maleimido ring structure through hydrolysis with nucleophilc neighboring effect and thus inhibit the undesired release reaction.

Structural Element: Aminoisobutyric Acid and Homologues

Aminoisobutyric acid (Aib) and its homologues are a strong helix promoters in peptide mimetics. Aib-containing model peptides are already used in cancer treatment, antimicrobial peptides and cell penetrating peptides (CPP).

We offer Aib and its homologues positioning the dimethyl fragment either close to the N- or to the C-terminus.

Synthesis of Protected Peptide Amide Fragments with Sieber Resin

Fmoc-Sieber amide resin is an acid-labile carrier for solid phase synthesis of peptide amides. Cleavage with only 1% TFA makes it an ideal carrier for the synthesis of protected peptide fragments in fragment condensation strategies for the synthesis of long peptides.

Amino-PEG-Acids for Increased Solubilization.

For introducing amino-PEG-acids into a peptide chain, several affordable building blocks are available with all conventional protecting groups. They can be incorporated at any sequence position by standard coupling protocols.

Custom Synthesis of Clicky Acids - Fatty Acids for Click Conjugation

Fatty Acids for Click Conjugation

Fatty acid residues and alkyl chains in general can improve solubility and anchoring in membranes and other Lipophilie environments.

Find a selection of promptly available short and long chain clickable acids in our web store. Any other – including functional groups for copper-free Click conjugation can be made on custom synthesis basis.

Polar Amino Acids for Increased Solubilization

alpha-Sulfo-beta-Alanine has been used to couple to hydrophobic molecules and peptides and increase solubility. Attachment can be carried out by conventional Fmoc/tBu protocols.