Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions without having to resort to complicated protecting group chemistry. Clickable groups include various tags and labels, as well as other biomolecules, such as carbohydrates. Furthermore, click chemistry facilitates otherwise challenging reactions such as peptide macrocyclization.

We offer an extensive selection of different propargyl amino acids for both Fmoc and Boc strategies, as well as unprotected propargyl amino acids for enzymatic peptide synthesis. Moreover, for your convenience, Iris supplies resins preloaded with propargyl amino acids.

• → Find azido-functionalized clickable PEGs, Poly-amino-acids and Dendrimers/Dendrons in our Drug Delivery section
• → Find azido-functionalized clickable Carbohydrates, Dyes, Labels and more in our Life Sciences section
• → Do you want to know more about Click Chemistry? Order our special catalogue “Everything for Click Chemistry” free of charge.
• → Can’t find the amino acid you need?
• → Need a linker for Cu-free Click Conjugation?

Inquire with our Custom Synthesis Service!

• Specific and quantitative labeling of biomolecules using click chemistry; K. Horisawa; Frontiers in physiology 2014; 5: 457. doi:10.3389/fphys.2014.00457
• Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide–alkyne “click” chemistry; J.-F. Lutz and Z. Zarafshani; Advanced Drug Delivery Reviews 2008; 60: 958-970. doi:http://dx.doi.org/10.1016/j.addr.2008.02.004 Click Chemistry as a Macrocyclization Tool in the Solid-Phase Synthesis of Small Cyclic Peptides; R. A. Turner, A. G. Oliver and R. S. Lokey; Organic Letters 2007; 9: 5011-5014. doi:10.1021/ol702228u
• Reprogramming Nonribosomal Peptide Synthetases for “Clickable” Amino Acids; H. Kries, R. Wachtel, A. Pabst, B. Wanner, D. Niquille and D. Hilvert; Angewandte Chemie International Edition 2014; 53: 10105-10108. doi:10.1002/anie.201405281
• Pyrrolysine Encoded by UAG in Archaea: Charging of a UAG-Decoding Specialized tRNA; G. Srinivasan, C. M. James and J. A. Krzycki; Science 2002; 296: 1459-1462. doi:10.1126/science.1069588
• Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair; S. M. Hancock, R. Uprety, A. Deiters and J. W. Chin; Journal of the American Chemical Society 2010; 132: 14819-14824. doi:10.1021/ja104609m