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Visit this regularly updated section to check out the latest additions to our portfolio, as well as the latest developments at Iris Biotech.
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Enzymatically Cleavable Linkers Based on Val-Cit and Val-Ala
The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.
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Trifluoromethylated Amino Acids
The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!
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PotM: Methanoprolines and Dimethylprolines - Constraining the Conformation of Peptides
Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.
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Clicky Acids – Fatty Acids for Click Conjugation
Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid derivatives suitable for Click Chemistry. Interested? Read on to find out more!
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About the Advantages of Pseudoproline Dipeptides
Serine- and Threonine-derived oxazolidines as well as Cysteine-derived thiazolidines, so-called Pseudoprolines, serve as structure-disrupting, solubilizing building blocks in peptide synthesis.
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Thiol- and Amine Reactive Crosslinkers
Iris Biotech offers hetero-bifunctional crosslinkers bearing an N-hydroxysuccinimide (NHS) ester and a maleimide group suitable for the reaction with amine- and thiol-containing molecules.
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PotM: Pyridyldithiols as Precursors for Disulfide-Based (Self-Immolative) Linkers
Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.
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Workshop Click Chemistry
You missed it? We are pleased to provide the full-length recording for your convenience! Any further questions? Please get in contact via info@iris-biotech.de!
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Fmoc-L-Cys(Palm)-OH – A S-palmitoylated Cysteine building block
Interested in studying the effect of palmitoylation on your peptide’s localization, function, and stability? Read on to find out more about the use of lipidated “fatty” amino acids!
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Facilitating the synthesis of hydrophobic peptides and proteins
Cys(Aapam): an Alloc protected Phacm linker as removable side chain modification for the incorporation of e.g. solubilizing tags facilitating the preparation of hydrophobic peptides and proteins.
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