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Visit this regularly updated section to check out the latest additions to our portfolio, as well as the latest developments at Iris Biotech.
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PotM: SIT – A New Cysteine Protecting Group
The new disulfide-based protecting group sec-isoamyl mercaptan (SIT) is fully compatible with Fmoc- and Boc-SPPS and can easily be removed reductively upon addition of dithiothreitol.
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Cyclopropyl Modification
Cyclopropanes represent important design elements in medicinal chemistry and are widely present in drug compounds. Read on to find out more about their full potential.
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Linkerology
Check out our latest video summarizing our capabilities and knowledge on linker technologies
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New Dawson Linker Derivatives
Interested in the formation of peptide thioesters for Native Chemical Ligation? Read on to find out more about the use of Dawson Linker derivatives as thioester surrogates compatible with Fmoc SPPS.
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Amino-Methylcoumarins as Fluorescent Labels
Enzymatically-activatable probes based on 7-amino-4-methylcoumarin (AMC) represent versatile tools for the detection and localization of proteolytic enzyme activities. Read on to find out more.
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Modifications of Methionine
Methionine is particularly prone to oxidation by atmospheric oxygen in vitro but also by reactive oxygen species in vivo, resulting in the corresponding sulfoxide and sulfone. Read on to find out more.
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Product of the Month: Fluorinated Amino Acids
One approach for the design of bioactive peptides with improved pharmacological properties is the derivatization of amino acid building blocks with fluorine. Find out more about the advantages of fluorinated peptides.
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Thiol-reactive Linkers for ADCs
The thiosuccinimide linkage is a prominent connective motif resulting from the reaction of a thiol and an alkyl maleimide. Read on to learn more about its applications and potential improvements.
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Product of the Month: Fluorescent SARS-CoV-2 Protease Substrates
Mpro is a key enzyme of coronaviruses (coronaviridae) and thus an attractive drug target. Iris Biotech offers fluorescent substrates, which can be used to perform various types of screenings and to identify potential inhibitors of COVID-19.
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