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Fmoc-L-His(Clt)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-im-2-chlorotrityl-L-histidine // Synonymes: Fmoc-His(Clt)-OH
- n° Art.:FAA1060
- n° CAS:224032-19-3
- Formule:C40H32ClN3O4
- Storage temperature:2-8°C
- Masse moléculaire:654,16 g/mol
from 190,00 €
description
The Clt (2-chlorotrityl) protecting group is more stable than the commonly used Trt group and is being cleaved with 90%TFA and thiol scavengers in dichloromethane. This property makes His(Clt) derivatives useful in the preparation of protected peptide fragments because the Trt-protection is in several cases not completely stable under the conditions required for the cleavage of protected peptides from 2-chlorotrityl resin.
references
Aletras A., Barlos K. et al; Int. J. Pept. Protein Res. 1995; 45(5): 488-496.
Barlos K. et al; Int. J. Pept. Protein Res. 1991; 38(6): 555-561.
Sarah L.M. et al, in „Fmoc Solid Phase Synthesis. A practical approach“, Ed.: Chan W.C., White P.D. Oxford University Press 2000, page 177.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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