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Fmoc-L-Sec(Mob)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-Se-(4-methoxybenzyl)-L-selenocysteine // Synonymes: Fmoc-L-Sec(pMeOBzl)-OH, Fmoc-L-Sec(Pmb)-OH, Fmoc-Sec(Mob), Fmoc-L-4-methoxybenzyl selenocysteine,(2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-[4-methoxybenzyl)selanyl]propionic acid, Fmoc-Sec( MPM), (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)a
- n° Art.:FAA8705
- n° CAS:150308-80-8
- Formule:C26H25NO5Se
- Storage temperature:2-8°C
- Masse moléculaire:510,46 g/mol
- Pureté:min. 99%
- Pureté Énantiomérique:min. 99,9%
from 90,00 €
description
Building block for the introduction of selenocysteine by SPPS. Peptides containing selenocysteine can be cleaved from the resin with simultaneous side-chain deprotection by treatment with 5% (v/v) water, 95% (v/v) trifluoroacetic acid (TFA), 0.4 M 2,2’-dithiobis(5-nitropyridine) (DTNP) for 7 min at 60 °C or 2 h at RT. See also FAA8710 Fmoc-D-Sec(Mob)-OH.
references
A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins; D. T. Cohen, C. Zhang, C. M. Fadzen, A. J. Mijalis, L. Hie, K. D. Johnson, Z. Shriver, O. Plante, S. J. Miller, S. L. Buchwald, B. L. Pentelute;
Nat. Chem. 2019; 11: 78-85. https://doi.org/10.1038/s41557-018-0154-0.
Chemical synthesis of ferredoxin with 4 selenocysteine residues using a segment condensation method; T. Takei, T. Ando, T. Takao, Y. Ohnishi, G. Kurisu, M. Iwaoka, H. Hojo; Chem. Commun. 2020; 56: 14239-14242; https://doi.org/10.1039/D0CC06252A.
Reassessment of an Innovative Insulin Analogue Excludes Protracted Action yet Highlights the Distinction between External and Internal Diselenide Bridges; B. Dhayalan, Y.-S. Chen, N. B. Phillips, M. Swain, N. K. Rege, A. Mirsalehi, M. Jarosinski, F. Ismail-Beigi, N. Metanis, M. A. Weiss; Chem. Eur. J. 2020; 26(21): 4695-4700. https://doi.org/10.1002/chem.202000309.
Copper-Mediated Selenazolidine Deprotection Enables One-Pot Chemical Synthesis of Challenging Proteins; Z. Zhao, N. Metanis; Angew. Chem. Int. Ed. 2019; 58(41): 14610-14614. https://doi.org/10.1002/anie.201909484.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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