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H-L-Sec(MDNPE)*TFA
Nom chimique: (2R)-2-amino-3-((1-(6-nitrobenzo[d][1,3]dioxol-5-yl)ethyl)selanyl)propanoic acid trifluoroacetate // Synonymes: 2235373-47-2 net, PSc, Photo-caged selenocysteine, H-sec(methyl-o-nitropiperonyl), Se-(methyl-o-nitropiperonyl)-selenocysteine,[(R,S)-1-[4',5'-(methylenedioxy)-2'-nitrophenyl]ethyl]-L-selenocysteine trifluoroacetate
- n° Art.:HAA9230
- n° CAS:2235373-48-3
- Formule:C12H14N2O6Se*CF3CO2H
- Storage temperature:-20°C
- Masse moléculaire:361,22*114,02 g/mol
- Pureté:min. 98%
- Pureté Énantiomérique:min. 99,7%
from 324,00 €
description
Sec allows the site-specific covalent protein modification, even in the presence of native cysteine, as the reactivity of a selenol group exceeds that of a thiol group. This photocaged selenocysteine (PSc) is incorporated as an unnatural amino acid in response to an amber stop codon using a mutant pyrrolysyl-tRNA/tRNA synthetase pair. Decaging can be achieved by irradiation with UV light (365 nm).
references
Site-Specific Incorporation of Selenocysteine by Genetic Encoding as a Photocaged Unnatural Amino Acid; A. P. Welegedara, L. A. Adams, T. Huber, B. Graham, G. Otting; Bioconjugate Chem. 2018; 29(7): 2257-2264. https://doi.org/10.1021/acs.bioconjchem.8b00254.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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