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H-L-Phe(4-N3)-OH
Nom chimique: 4-Azido-L-phenylalanine // Synonymes: H-Phe(4-N3)-O
- n° Art.:HAA1850
- n° CAS:33173-53-4
- Formule:C9H10N4O2
- Storage temperature:-20°C
- Masse moléculaire:206,20 g/mol
- Pureté:min. 99%
- Pureté Énantiomérique:min. 99,9%
from 108,00 €
description
H-Phe(4-N3) is used in protein biosynthesis as unnatural amino acid for genetic code expansion. The azido-funcionality can be further utilized to cross-link various functionalities to proteins utilizing click-chemistry.
The azido-functionality is IR-active and can be used in protein active site electrostatic environment studies. Ye, Shixin; Huber, Thomas; Vogel, Reiner; Sakmar, Thomas P. Nature Chemical Biology (2009), 5(6), 397-399. DOI:10.1038/nchembio.167;
The azide-handle can also be used for protein PEGylation or attachment to antibodies using click-chemistry.
Wilding, Kristen M.; Smith, Addison K.; Wilkerson, Joshua W.; Bush, Derek B.; Knotts, Thomas A.; Bundy, Bradley C. ACS Synthetic Biology (2018), 7(2), 510-521. DOI:10.1021/acssynbio.7b00316;
Doronina, Svetlana O.; Kline, Toni Beth U.S. (2018), US 10000555 B2.
references
Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher; Mukherji, Mridul; Zhang, Zhiwen; Schultz, Peter G. Science (2003), 301(5635), 964-967. DOI:10.1126/science.1084772;
Neumann, Heinz; Wang, Kaihang; Davis, Lloyd; Garcia-Alai, Maria; Chin, Jason W. Nature (2010), 464(7287), 441-444. DOI:10.1038/nature08817;
Rovner, Alexis J.; Haimovich, Adrian D.; Katz, Spencer R.; Li, Zhe; Grome, Michael W.; Gassaway, Brandon M.;
Amiram, Miriam; Patel, Jaymin R.; Gallagher, Ryan R.; Rinehart, Jesse; et al Nature (2015), 518(7537), 89-93. DOI:10.1038/nature14095;
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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