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H-L-Lys(N3)-OH
Nom chimique: N-epsilon-azido-L-lysine // Synonymes: 6-azido-L-norleucine, L-azidonorleucine, H-Nle(6-N3)-OH, (S)-6-azido-2-amino-hexanoic acid, L-azidolysine, Anl, Epsilon-azido-L-norleucine, H-Lys(N3)-OH
- n° Art.:HAA9210
- n° CAS:159610-92-1
- Formule:C6H12N4O2
- Storage temperature:2-8°C
- Masse moléculaire:172,19 g/mol
- Pureté:min. 99%
- Pureté Énantiomérique:min. 99,7%
from 65,00 €
description
H-Lys(N3)-OH is incorporated into proteins that can be further selectively modified using Staudinger ligation or Click-chemistry.
references
Presentation and Detection of Azide Functionality in Bacterial Cell Surface Proteins; A. J. Link, M. K. S. Vink, D. A. Tirrell; J. Am. Chem. Soc. 2004; 126(34): 10598-10602. https://doi.org/10.1021/ja047629c.
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids; A. J. Link, M. K. S. Vink, N. J. Agard, J. A. Prescher, C. R. Bertozzi, D. A. Tirrell; PNAS 2006; 103(27): 10180-10185. https://doi.org/10.1073/pnas.0601167103.
Discovery of Escherichia coli methionyl-tRNA synthetase mutants for efficient labeling of proteins with azidonorleucine in vivo; I. C. Tanrikulu, E. Schmitt, Y. Mechulam, W. A. Goddard III, D. A. Tirrell; PNAS 2009; 106(36): 15285-15290. https://doi.org/10.1073/pnas.0905735106.
Orthogonal Alkynyl Amino Acid Reporter for Selective Labeling of Bacterial Proteomes during Infection; M. Grammel, M. M. Zhang, H. C. Hang; Angew. Chem. Int. Ed. 2010; 49(34): 5970-5974. https://doi.org/10.1002/anie.201002050.
Site-Specifically Phosphorylated Lysine Peptides; J. Bertran-Vicente, R. A. Serwa, M. Schümann, P. Schmieder, E. Krause, C. P. R. Hackenberger; J. Am. Chem. Soc. 2014; 136(39): 13622-13628. https://doi.org/10.1021/ja507886s.
Remote C-H Hydroxylation by an alpha-Ketoglutarate-Dependent Dioxygenase Enables Efficient Chemoenzymatic Synthesis of Manzacidin C and Proline Analogs; C. R. Zwick, H. Renata; J. Am. Chem. Soc. 2018; 140(3): 1165-1169. https://doi.org/10.1021/jacs.7b12918.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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