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H-L-Lys(Norbornene-methoxycarbonyl)-OH*HCl
Nom chimique: N-epsilon-(norbornene-methoxycarbonyl)-L-lysine hydrochloride // Synonymes: N6-((bicyclo[2.2.1]hept-5-en-2-ylmethoxy)carbonyl)-L-lysine hydrochloride, H-Lys(norbornene-methoxycarbonyl)-OH*HCl
- n° Art.:HAA9235
- n° CAS:1378916-76-7
- Formule:C15H24N2O4*HCl
- Storage temperature:-20°C
- Masse moléculaire:296,37*36,46 g/mol
- Pureté:min. 95%
from 375,00 €
description
One popular technique for the modification of proteins is based on the incorporation of genetically encoded non-natural amino acids by using biorthogonal tRNA/tRNA-synthetase pairs. This norbornene-derivatized lysine can be click-functionalized with azides partially under Cu(I) catalysis or with tetrazines in Diels-Alder reactions with inverse electron demand. Both wildtype and specifically mutated pyrrolysine synthetases (PyIRSs) are reported to load this noncanonical amino acid onto the cognate pyrrolysine tRNA.
This product is a mixture of two isomers.
references
Structural insights into incorporation of norbornene amino acids for click modification of proteins; S. Schneider, M. J. Gattner, M. Vrabel, V. Fluegel, V. Lopez-Carrillo, S. Prill, T. Carell; ChemBioChem 2013; 14(16): 2114-2118. https://doi.org/10.1002/cbic.201300435.
A need for speed: genetic encoding of rapid cycloaddition chemistries for protein labelling in living cells; M. J. Schmidt, D. Summerer; ChemBioChem 2012; 13(11): 1553-1557. https://doi.org/10.1002/cbic.201200321.
A genetically encoded norbornene amino acid for the mild and selective modification of proteins in a copper-free click reaction; E. Kaya, M. Vrabel, C. Deiml, S. Prill, V. S. Fluxa, T. Carell; Angew. Chem. Int. Ed. 2012; 51(18): 4466-4469. https://doi.org/10.1002/anie.201109252.
Amino Acids for Diels-Alder Reactions in Living Cells; T. Plass, S. Milles, C. Koehler, J. Szymansk, R. Mueller, M. Wiessler, C. Schultz, E. A. Lemke; Angew. Chem. Int. Ed. 2012; 51(17): 4166-4170. https://doi.org/10.1002/anie.201108231.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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