Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Custom Synthesis
We are carrying out many Contract Manufacturing projects in these areas (cGMP and ISO9000); our strong points are unusual derivatives with one or several chiral centres.
Our Mission
is to accompany our customers during their projects from R&D to Production as highly qualified supplier. We deliver lab quantities to research units for very competitive prices and supply increasing quantities with same quality and specifications during the evolution of our customers' products to pilot scale and even multi-ton commercial productions with bulk quantities.
Our Productions
We are cooperating with around 35 selected manufacturers and leading universities worldwide with specific expertise in the areas of our activities. All our manufacturing partners go through an intensive and detailed supplier qualification program.
See some examples for Custom Synthesis Projects here
- Standard approaches Diethyl-acetamidomalonate Route: The probably most widely used first approach to unnatural amino acids goes via alkylation of diethyl acetamidomalonate. This process is daily routine in our laboratories and is an easy access to a large number of analogues in gram scale. This ...
- Specific platforms Asymmetric Phase-Transfer Reaction Phase-transfer alkylations e.g. with the chiral Maruoka catalyst result in unique α-mono substituted and α,α-disubstituted unnatural amino acids. Typically such building blocks implemented in peptides increase the chemical and metabolic ...
- Homologization of natural amino acids Several platforms are available to display the whole assortment of homo-amino acids, as well as the higher homologues β2-, β3-, their double substituted derivatives β2,2,2-, β3,3-, and corresponding γ-amino acids. Using e.g. via 4-benzyloxazolidin-2-one templates ...
- α-Methyl and β,β-dimethyl amino acids α-Methyl and alkyl-amino acids can be produced by a number of platforms, where the (2S,4S)-4-methyl-2-phenyloxazolidin-5-one scaffold is one of the most popular one. We optimize published procedures and have own proprietary ones, which enable us to supply all kinds of protected ...
- Trifluoromethylated and other Fluoro-amino acids The incorporation of trifluoromethyl group carrying building blocks into peptides results in increased chemical and thermal stability, increased resistance to degradation by proteases, and enhanced lipophilicity. Trifluoromethyl group bearing peptides will therefore show a better ...
- Arginine Analogues Trypsin (EC 3.4.21.4), an endopeptidase and natural protease found in the digestive system, cleaves peptide chains and proteins predominantly at the carboxyl side of the amino acids Lys and Arg (except when followed by Pro). Peptides and proteins are gaining importance as modern ...
- Proline Scaffold One role of proline in proteins is that a β-turn of a peptide chain is being induced at its position. Two major conformations, cis or trans, of the corresponding amid bond will induce that the protein folds in a specific way. While the trans-conformation is normally ...
- Specific Linkers The variations for linkers are endless, as in our catalogue program already hundreds of different derivatives are available for conjugation of small molecules, biomolecules and surfaces to each other. In the following we demonstrate a few examples with their specific properties. ...
- Spermines, spermidines and other Polyamines Polyamines such as ethylene diamine and its higher homologues are important feedstocks for the chemical industry. Compounds like putrescine, spermidine, and spermine play important roles in both eukaryotic and prokaryotic cells and show many other different biological functions. Most ...
- Maillard Reaction Products Proteins contained in meat and other comestible goods are usually rich in the amino acids arginine and lysine. The side chain func- tional groups of Arg and Lys react with reducing carbohydrates such as glucose or lactose to form Amadori reaction products. These characteristic ...
