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Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying through a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.
Continue to Iris Biotech GmbHSend request to US distributorChemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-beta,beta-dimethyl-D-serine // Synonyms: Boc-D-Hvl-OH, (R)-Boc-beta-hydroxy-valine, (R)-Boc-2-amino-3-hydroxy-3-methyl-butyric acid, (R)-Boc-beta,beta-dimethyl-serine,(R)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-methylbutanoic acid
from €1,375.00
beta,beta-Dimethylation of amino acids stabilizes appropriate peptides towards digestion by proteases. The hydroxyl function of this serine building block is unprotected, because acylation does not happen to tertiary alcohols during standard Boc/Bzl coupling protocols.
A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates; Kathryn R. Heard, Wengen Wu, Youhua Li, Peng Zhao, Iwona Woznica, Jack H. Lai, Martin Beinborn, David G. Sanford, Matthew T. Dimare, Amrita K. Chiluwal, Diane E. Peters, Danielle Whicher, James L. Sudmeier, and William W. Bachovchin; J. Med. Chem. 2013; 56: 8339−8351. dx.doi.org/10.1021/jm400423p.
Total synthesis of the large non-ribosomal peptide polytheonamide B; Masayuki Inoue, Naoki Shinohara, Shintaro Tanabe, Tomoaki Takahashi, Ken Okura,Hiroaki Itoh, Yuki Mizoguchi, Maiko Iida, Nayoung Lee and Shigeru Matsuoka; Nature Chem. 2010; 2: 281-285. DOI: 10.1038/nchem.554.
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