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Fmoc-L-Ser(TBDMS)-OH
- Product code:FAA6510
- CAS No.:146346-81-8
- Formula:C24H30NO5Si
- Storage temperature:2-8°C
- Molecular weight:441.60 g/mol
from €170.00
description
The TBDMS protecting group of the serine hydroxy function is more labile towards TFA than tBu and can selectively be cleaved in the presence of Boc/tBu with tetrabutylammonium fluoride in DMF. However, Fmoc is also being removed under these conditions!
references
Fischer P.M.; Tetrahedron Lett. 1992; 33: 7605.
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