Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Quick contact
Please send me more information about
Fmoc-D-Ser(Msbh)-OH
Chemical name: N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(bis(4-(methylsulfinyl)phenyl)methyl)-D-serine // Synonyms: Safety-Catch D-Serine
- Product code:FAA8837
- Storage temperature:2-8°C
- Formula:C33H31NO7S2
- Molecular weight:617.73 g/mol
from Please inquire
description
MsbH is a safety-catch protecting group for cysteines, serines and threonines. It is stable to the conditions applied in both Boc and Fmoc chemistry. By reduction of the sulfoxides to thioethers with NH4I and dimethylsulfide in TFA, the MsbH protection becomes instable and is instantly removed.
references
The p-(methylsulfinyl)benzyl group: a trifluoroacetic acid (TFA)-stable carboxyl-protecting group readily convertible to a TFA-labile group; J. M. Samanen, E. Brandeis; J. Org. Chem. 1988; 53(3): 561-569. https://doi.org/10.1021/jo00238a016
Solid-Phase Synthesis Using a Four-Dimensional (Safety-Catch) Protecting Group Scheme; F. Albericio, S. Noki, E. Brasil, H. Zhang, T. Bruckdorfer, B. G. de la Torre; J. Org. Chem. 2022; 87: 9443-9453. https://doi.org/10.1021/acs.joc.2c01056
Do you need further information about this product?
get in contact
We found other products you might like!
