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Linkerology
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HMPO: A pH-Responsive Linker for Targeted Drug Delivery
HMPO (5-(hydroxymethyl)pyrogallol orthoester), a plasma-stable, pH-sensitive, 1,6-self-immolative crosslinker derived from the natural product gallic acid. Discover its properties!
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GGFG Motif for ADC Construction
To address both chemical and IP considerations in self-immolating linker applications, we propose shifting from the commonly used Val-Cit-PAB linker to the less explored Gly-Gly-Phe-Gly-formyl motif.
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Linkerology® for Targeted Delivery and Release
Use the possibilities of Linkerology® to boost the efficacy of your drug! We illustrate how the drug Gepirone (ExxuaTM), a medication to treat major depressive disorders, can be conjugated.
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Phenylboronate Amino Acid Building Blocks
Boron is not boring at all! Today, we'll delve deeper into the exciting world of boronate-containing amino acid building blocks and unlock the potential of the next generation of peptides. Read on!
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Linkerology® - An Example of Advanced Conjugation
The targeted delivery and traceless release of drugs is an important concept in pharmacology. Discover the possibilities of payload conjugation to carrier proteins shown for the example drug Elacestrant.
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Combination Therapy & Linkerology®
Discover possibilities to fight chronic pain diseases by employing linker technologies. Check out the options for multiple drug conjugation in combination with different release mechanisms.
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Linkerology® on Metal & Ore Surfaces
A heart of gold! Metals and ores - see here how their surfaces can be equipped with bifunctional organic linker molecules and thus be turned into modifiable biocompatible materials.
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PotM: Multiconjugates via Simultaneous Double-Click Reaction
Discover our new building block 4-(azido-propyl-tetrazine)phenylalanine (pTAF) and make use of the orthogonality of the 2nd and 3rd generation Click reaction to build multiconjugates via double-Click.
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Conjugating Small Molecule Drugs
You want to attach your small molecule to a certain carrier? Let’s analyze the functional groups present and discuss Linkerology® possibilities for permanent or trigger-inducible, tracelessly-cleavable linkage.
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Cell-Free Bioengineering & Linkerology®
Bioengineering in combination with Linkerology®. Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.
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