Welcome to Iris Biotech
For better service please confirm your country and language we detected.
confirm selection
For better service please confirm your country and language we detected.
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying through a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.
Continue to Iris Biotech GmbHSend request to US distributorPublished on 15/01/2025
In the following, we are focusing on the highlights of our 2024 portfolio additions during the second half of the year. Of course, many more derivatives were added, especially in terms of unnatural amino acids. If you cannot find the building block you are looking for, get in contact!
Major innovations can be reported for the product classes resins and linkerology®.
For the well-known solid support TentaGel® - low cross-linked polystyrene beads on which poly(ethylene glycol) is grafted – we presented our preloaded resins RAI1202 and RAI1217, carrying labeled (13C and 15N9) L-lysine and L-arginine, respectively, allowing for the easy production of labeled peptides and their detection by mass spectrometry or NMR. In the context of DNA synthesis, we are now offering TentaGel® resins preloaded with dimethoxytrityl-protected deoxynucleosides (N300021, N300022, N300023, N300024). Besides, we provide the TentaGel® resin TGJ1002, which carries a cleavable 3 kDa PEG spacer and can be used to create PEGylated molecules (e.g., N-terminally PEGylated peptides) via SPPS. A more detailed overview is given in our blog: https://iris-biotech.de/blog/potm-versatile-tentagelr-resins.html
In contrast to polystyrene-based resins, we introduced Amino-Li Resin (BR-1045), a cross-linked polyacrylic amide solid support suitable for the synthesis of peptides and biomolecules, which is compatible with organic as well as aqueous solvents. High swelling is reported, e.g., about 6 ml/g in DMF, DMSO and NBP, about 7 ml/g in water, and about 8 ml/g in DCM, but the resin is also compatible with some non-polar reaction media. For available preloaded derivatives, see our blog: https://iris-biotech.de/blog/amino-li-resin-a-novel-solid-support.html
For greener peptide synthesis, we presented Cyclover-Amine (CC-1000), a novel soluble tag combining the advantages of both, liquid and solid-phase synthesis. Cyclophase synthesis runs in repetitive cycles of dissolving, reacting, and precipitating, and allows the avoidance of DMF. For more details, see our blog: https://iris-biotech.de/blog/potm-cyclover-amine-for-peptide-and-oligonucleotide-synthesis.html
In terms of linker technologies, we highlighted HMPO (ADC1800), a plasma-stable, pH-responsive, 1,6-self-immolative linker for targeted drug delivery, being cleaved at acidic pH thus releasing the conjugated payload.
In the field of peptidic ADC linkers cleavable by cathepsin proteases, we reported on Gly-Gly-Phe-Gly linkers. Patritumab-Deruxtecan is the first ADC which uses the tetrapeptide GGFG. In 2022, phase I escalation studies have been published with promising results.
As maleimide alternative for the modification of and conjugation to cysteine side chain functional groups of peptides, we enriched our toolbox by 5-hydroxy-1,5-dihydro-2H-pyrrol-2-one derivatives (5HP2Os). Members of this family avoid the typical maleimide-drawbacks such as hydrolysis, retro-Michael reactions, and/or thiol exchange reactions. For more information, watch the recording of our online-workshop about furan and a maleimide replacement technology!
Regarding selective N-terminal peptide and protein modification, https://iris-biotech.de/blog/a-triazolecarbaldehyde-for-selective-n-terminal-protein-modification.html we added a triazolecarbaldhyde linker (RL-8650).
Last but not least, related to life sciences, we introduced CysGluDan (LS-4665), a fluorescent probe that captures both “hard and soft” reactive metabolites under formation of a stable thiazolidine ring structure. In contrast, Dansyl-labeled GSH (HAA7945) is only suitable for soft electrophiles. More details and references are summarized in our blog.
Moreover, several new maillard reaction products were developed. A complete list is available in our webshop.
You are looking for a different building block or special functionalization not listed in our portfolio? Get in contact for a Custom Synthesis or browse our brochure to get an overview about our capabilities!